For: Skene's gland For: Prostration

The prostate (from Greek προστάτης - prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male mammalian reproductive system. Females also have prostate glands, previously called paraurethral or Skene's glands, connected to the distal third of the urethra in the prevaginal space.

The prostate differs considerably among species anatomically, chemically, and physiologically.

Function

The main function of the prostate is to store and secrete a slightly alkaline (pH 7.29) fluid, milky or white in appearance,

The prostate also contains some smooth muscles that help expel semen during ejaculation.

Secretions

Prostatic secretions vary among species. They are generally composed of simple sugars, and are often slightly alkaline.

In human prostatic secretions, the protein content is less than 1% and includes proteolytic enzymes, prostatic acid phosphatase, and prostate-specific antigen. The secretions also contain zinc with a concentration 500-1,000 times the concentration in blood.

Regulation

To work properly, the prostate needs male hormones (androgens), which are responsible for male sex characteristics.

The main male hormone is testosterone, which is produced mainly by the testicles. Some male hormones are produced in small amounts by the adrenal glands. However, it is dihydrotestosterone that regulates the prostate.

Development

The prostatic part of the urethra develops from the pelvic (middle) part of the urogenital sinus (endodermal origin). Endodermal outgrowths arise from the prostatic part of the urethra and grow into the surrounding mesenchyme. The glandular epithelium of the prostate differentiates from these endodermal cells, and the associated mesenchyme differentiates into the dense stroma and the smooth muscle of the prostate. The prostate glands represent the modified wall of the proximal portion of the male urethra and arises by the 9th week of embryonic life in the development of the reproductive system. Condensation of mesenchyme, urethra and Wolffian ducts gives rise to the adult prostate gland, a composite organ made up of several glandular and non-glandular components tightly fused within a common capsule.

Female prostate gland

The Skene's gland, also known as the paraurethral gland, found in females, is homologous to the prostate gland in males. In 2002, the Skene's gland, was officially renamed the prostate by the Federative International Committee on Anatomical Terminology.

The female prostate, like the male prostate, secretes PSA and levels of this antigen rise in the presence of carcinoma of the gland. The gland also expels fluid, like the male prostate, during orgasm. Researchers argue that the organ should therefore be called a female prostate and not "Skene's gland".