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The National Cancer Institute (NCI) is part of the United States Federal government's National Institutes of Health. The NCI is a federally funded research and development center, one of eight agencies that compose the Public Health Service in the United States Department of Health and Human Services. As of September 2006, the current director of the NCI is Dr. John E. Niederhuber. The NCI coordinates the National Cancer Program.

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Wikipedia About National Cancer Institute

The National Cancer Institute (NCI) is part of the United States Federal government's National Institutes of Health. The NCI is a federally funded research and development center, one of eight agencies that compose the Public Health Service in the United States Department of Health and Human Services. As of September 2006, the current director of the NCI is Dr. John E. Niederhuber. The NCI coordinates the National Cancer Program.

The National Cancer Institute has large intramural research programs in Bethesda, Maryland and NCI-Frederick at Fort Detrick, in Frederick, Maryland. In addition, the NCI funds cancer researchers around the United States.

Legislative history

Congress established the NCI by the National Cancer Institute Act, August 5, 1937, as an independent research institute. Congress then made the NCI an operating division of the National Institutes of Health by the Public Health Service Act, July 1, 1944. Congress amended the Public Health Service Act with the National Cancer Act of 1971 to broaden the scope and responsibilities of the NCI "in order more effectively to carry out the national effort against cancer." Over the years, legislative amendments have maintained the NCI authorities and responsibilities and added new information dissemination mandates as well as a requirement to assess the incorporation of state-of-the-art cancer treatments into clinical practice.

Anti-cancer drug investigations

The NCI played an early role in the development of anti-cancer drugs in the U.S. According to a 1996 NCI analysis of drugs approved by the FDA, two-thirds of the anti-cancer drugs approved as of the end of 1995 were NCI-sponsored Investigational New Drugs:

Alkylating agents .

  • Chlorambucil (Leukeran) (1957)
  • Cyclophosphamide (Cytoxan) (1959)
  • Thiotepa (1959)
  • Melphalan (Alkeran) (1959) (IV in 1993)
  • Streptozotocin (Zanosar) (1982)
  • Ifosfamide (Ifex) (1988)

Antimetabolites

  • Mercaptopurine (1953)
  • Methotrexate (1953)
  • Thioguanine (1966)
  • Cytosine arabinoside (Ara-C) (1969)
  • Floxuridine (FUDR) (1970)
  • Fludarabine phosphate (1991)
  • Pentostatin (1991)
  • Chlorodeoxyadenosine (1992)

Plant alkaloids and antibiotics

Vincristine.png

  • Vincristine (Oncovin) (1963)
  • Actinomycin D (Cosmegen) (1964)
  • Mithramycin (Mithracin) (1970)
  • Bleomycin (Blenoxane) (1973)
  • Doxorubicin (Adriamycin) (1974)
  • Mitomycin C (Mutamycin) (1974)
  • L-Asparaginase (Elspar) (1978)
  • Daunomycin (Cerubidine) (1979)
  • VP-16-213 (Etoposide) (1983)
  • VM-26 (Teniposide) (1992)
  • Taxol (Paclitaxel) (1992)

Search results for National Cancer Institute

National Cancer Institute Publications Locator Home

Welcome to National Cancer Institute Publications Locator where you can view or order NCI publications ... your order by calling 1-800-4-CANCER (1-800-422-6237) ...https://cissecure.nci.nih.gov/ncipubs/

Clinical Trials Home Page - National Cancer Institute

Information from the National Cancer Institute on how to find cancer clinical trials, what clinical trials are, recent research, resources for researchers.cancertrials.nci.nih.gov/clinicaltrials

NCI Alliance for Nanotechnology in Cancer

National Cancer Institute. U.S. National Institutes of Health | www.cancer.gov. NCI Alliance for ... A Service of the National Cancer Institute ...nano.cancer.gov/

Surveillance, Epidemiology, and End Results Program

The SEER Program of the National Cancer Institute collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 14% of the U.S. population.www.seer.cancer.gov/

National Cancer Institute, Extramural Activities

President's Cancer Panel, Board of Scientific Advisors, National Cancer Advisory ... Latest news and events at the National Cancer Institute. NIH Research Portfolio ...deainfo.nci.nih.gov/

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News about National Cancer Institute

Surveillance Mammography After Treatment For Primary Breast Cancer

Medical News TodayThe National Institute for Health Research Health Technology Assessment (NIHR HTA) programme has commissioned a new study to identify the most effective and efficient surveillance methods for women who have received treatment for primary breast cancer.http://www.medicalnewstoday.com/articles/121465.php

Doctors use multimedia to increase colorectal cancer screening among Hispanics

UC Newsroom$2.7 million National Cancer Institute grant will be used to refine custom-designed software piloted at UC Davis.http://www.universityofcalifornia.edu/news/article/18567

Tools to boost cancer treatments published

Moldova.orgU.S. researchers say they have created a set of research tools designed to make the development of new cancer treatments more efficient.The Translational Research Working Group at the U.S. National Cancer Institute said their tools are known as Pathways to Clinical Goals.The NCI supports a great deal of excellent translational research but inefficiencies arising from a lack of communication and .....http://it.moldova.org/stiri/eng/150321/

DNA Vaccine Developed at the Karmanos Cancer Institute Fights HER2-Positive Cancers

PR Newswire via Yahoo! News Researchers at the Barbara Ann Karmanos Cancer Institute and Wayne State University School of Medicine have developed a HER2 DNA vaccine that has shown to be effective on drug resistant tumors in mice. The study was reported in the September 15 issue of Cancer Research, a journal of the American Association for Cancer Research.http://news.yahoo.com/s/usnw/20080915/pl_usnw/dna_vaccine_de...

New Cancer Stem Cell Marker Identified By OU Cancer Institute

Medical News TodayAfter years of working toward this goal, scientists at the OU Cancer Institute have found a way to isolate cancer stem cells in tumors so they can target the cells and kill them, keeping cancer from returning. A research team led by Courtney Houchen, M.D., and Shrikant Anant, Ph.D., discovered that a particular protein only appears in stem cells.http://www.medicalnewstoday.com/articles/121316.php

News about National Cancer Institute

Agency: NASA center buildings didn't cause cancer

Houston ChronicleCLEVELAND — A federal health agency has determined that two buildings at the NASA Glenn research center in Cleveland did not cause cancer among 65 past and present employees. The National Institute for Occupational Safety and Health released the ... http://www.chron.com/disp/story.mpl/space/6047270.html

Study: Aspirin, ibuprofen may cut breast cancer risk

CNNThe findings were published this week in the Journal of the National Cancer Institute . While it might be tempting to try to reduce your own risk by popping these over-the-counter pain relievers, known as nonsteroidal anti-inflammatory drugs (NSAIDs ... http://www.cnn.com/2008/HEALTH/conditions/10/08/breast.cance...

Tamoxifen Speeds Diagnosis of ER-Negative Breast Cancer

Washington PostThe study was published online Oct. 7 in theJournal of the National Cancer Institute. The findings should be investigated further, the researchers concluded. More information The National Cancer Institute has more about tamoxifen . SOURCE:Journal of ... http://www.washingtonpost.com/wp-dyn/content/article/2008/10...

Pink ribbons overshadow deadlier cancer

Detroit NewsLung cancer is by far the leading cause of cancer deaths among both men and women, according to the National Cancer Institute. It kills more Americans each year than breast, prostate, colorectal and pancreatic cancers combined. Yet, lung cancer only ... http://www.detnews.com/apps/pbcs.dll/article?AID=/20081008/O...

Painkillers 'cut breast cancer'

BBC NewsThe research, which looked at information from 2.7 million women, was published in the Journal of the National Cancer Institute. Aspirin cut the risk by 13%, while ibuprofen lowered it by a fifth. However, experts warned long-term use of ... http://news.bbc.co.uk/1/hi/health/7658472.stm

Search results for National Cancer Institute

National Cancer Institute - CIP Home

Investigators Access detailed information on open and closed funding opportunities, grant mechanisms, and application guidelines. more > Patients & Providershttp://imaging.cancer.gov/

Oxford Journals | Medicine | JNCI J Natl Cancer Inst

JNCI: Journal of the National Cancer Institute ... Advance Access Browse the archive Browse by subject. Highlights . NSAID Use ... http://jnci.oxfordjournals.org/

Calendar of Events - National Cancer Institute

The NCI Calendar of Scientific Meetings has been discontinued. Please look for information about onsite NCI meetings and conferences in the National Institutes of Health (NIH ... http://calendar.cancer.gov/

Cancer Centers Program - Huntsman Cancer ...

Huntsman Cancer Institute (HCI) at the University of Utah is the only National Cancer Institute-designated cancer center in the ... http://cancercenters.cancer.gov/cancer_centers/hci.html

National Cancer Institute of Canada

Research Connection Read the fall issue of our e-newsletter for researchers. Special call for lung cancer applications Funding opportunity provided by the Ontario Division of the ... http://www.ncic.cancer.ca/
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Answers for National Cancer Institute

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