this: the disorder

Migraine is a neurological syndrome characterized by altered bodily experiences, painful headaches, and nausea. It is a common condition which affects women more frequently than men.

The typical migraine headache is one-sided and pulsating, lasting 4 to 72 hours. Accompanying complaints are nausea and vomiting, and a heightened sensitivity to bright lights (photophobia) and noise (hyperacusis). Approximately one third of people who experience migraines get a preceding aura, in which a patient may sense a strange light or unpleasant smell.

Although the exact cause of migraine remains unknown, the most widespread theory is that it is a disorder of the serotonergic control system. Recently, PET scans have demonstrated the aura to coincide with spreading cortical depression after an episode of greatly increased blood flow (up to 300% higher than baseline). There also appear to be migraine variants that originate in the brainstem and involve dysfunction in calcium and potassium ion transport between cell membranes. Genetic factors may also contribute. Studies on twins show that genes have a 60 to 65% influence on the development of migraine. Fluctuating hormone levels show a relation to migraine in several ways: three quarters of adult migraine patients are female while migraine affects approximately equal numbers of boys and girls before puberty,Fact: date=November 2007 and migraine is known to disappear during pregnancy in a substantial number of sufferers.

The treatment of migraine begins with simple painkillers for headache and anti-emetics for nausea, and avoidance of triggers if present. Specific anti-migraine drugs can be used to treat migraine. If the condition is severe and frequent enough, preventative drugs might be considered.

The word migraine is French in origin and comes from the Greek hemicrania, as does the Old English term megrim. Literally, hemicrania means "half (the) head".

Classification

Migraines have been classified by the International Headache Society which periodically revises their classification. Complete supplement online

Defining severity of pain

In addition to classifying the type of headache, the International Headache Society defines intensity of pain on a verbal 4-point scale: Complete supplement online (see page 150)

Migraine without aura

This is the most commonly seen form of migraine; patients who primarily suffer from migraine without aura may also have attacks of migraine with aura. The International Classification of Headache Disorders defines this condition as follows: