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Methadone (Dolophine, Amidone, Methadose, Physeptone, Heptadon and many others) is a synthetic opioid, used medically as an analgesic, antitussive and a maintenance anti-addictive for use in patients on opioids. It was developed in Nazi Germany in 1937. Although chemically unlike morphine or heroin, methadone also acts on the opioid receptors and thus produces many of the same effects. Methadone is also used in managing chronic pain due to its long duration of action and very low cost. In late 2004, the cost of a one-month supply of methadone was $20, as compared to an equivalent analgesic amount of meperidine (pethidine) at $120, up to $500 and more for hydromorphone, morphine, fentanyl, and extended-release oxymorphone.

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Wikipedia About Methadone

Methadone (Dolophine, Amidone, Methadose, Physeptone, Heptadon and many others) is a synthetic opioid, used medically as an analgesic, antitussive and a maintenance anti-addictive for use in patients on opioids. It was developed in Nazi Germany in 1937. Although chemically unlike morphine or heroin, methadone also acts on the opioid receptors and thus produces many of the same effects. Methadone is also used in managing chronic pain due to its long duration of action and very low cost. In late 2004, the cost of a one-month supply of methadone was $20, as compared to an equivalent analgesic amount of meperidine (pethidine) at $120, up to $500 and more for hydromorphone, morphine, fentanyl, and extended-release oxymorphone.

Methadone's usefulness in treatment of opioid dependence is the result of several factors. It has cross-tolerance with other opioids including heroin and morphine, long duration of effects with the result that oral dosing with methadone will stabilise the condition of the patient by stopping and preventing the opioid withdrawal syndrome, and by at least partially blocking the "rush" resulting from intravenous injection of heroin, morphine, and similar drugs.

Today a number of pharmaceutical companies produce and distribute methadone, with only the racemic hydrochloride being available in the United States as of March 2008 but the tartrate and other salts of the laevorotary form (levomethadone, with trade names like Polamidone, Heptadon etc.), which is more potent and lacks the cardiac effects like lengthened QT interval caused by the dextrorotary form, being available in Europe and elsewhere. The major producer remains Mallinckrodt. Mallinckrodt sells bulk methadone to most of the producers of generic preparations and also distributes its own brand name product in the form of tablets, dispersible tablets and oral concentrate under the name Methadose in the United States.

History

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The drug was given the trade name Dolophine from the Latin dolor meaning pain (Cf. Dipidolor for piritramide, Dolantin for pethidine, and the "-dol" ending in so many trade and chemical names for analgesics of all types in German, English, French, and other languages) and was not named either in honour of or personally by Adolf Hitler as explored in greater detail below.

On September 11, 1941 Bockmühl and Ehrhart filed an application for a patent for a synthetic substance they called Hoechst 10820 or polamidon (a name still in regular use in Germany) and whose structure had no relation to morphine or the opiate alkaloids (Bockmühl and Ehrhart, 1949).

Methadone was introduced into the United States in 1947 by Eli Lilly and Company as an analgesic (they gave it the trade name Dolophine, which is now registered to Roxane Laboratories). Since then, it has been best known for its use in treating narcotic addiction. A great deal of anecdotal evidence was available "on the street" that methadone might prove effective in treating heroin withdrawal and it had even been used in some hospitals. It was not until studies performed at the Rockefeller University in New York City by Professor Vincent Dole, along with Marie Nyswander and Mary Jeanne Kreek, that methadone was systematically studied as a potential substitution therapy. Their studies introduced a sweeping change in the notion that drug addiction was not necessarily a simple character flaw, but rather a disorder to be treated in the same way as other diseases. To date, methadone maintenance therapy has been the most systematically studied and most successful, and most politically polarizing, of any pharmacotherapy for the treatment of drug addiction patients.

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methadone: Definition from Answers.com

More about Methadone: Purpose Precautions Preparation Aftercare Risks Side effects Normal results Resources Methadone Definition Methadone is awww.answers.com/topic/methadone

Fact Sheet: Methadone

Methadone occupies this receptor and is the stabilizing ... cause methadone is effective in eliminating withdrawal ... Methadone is a legal medication produced ...www.whitehousedrugpolicy.gov/publications/pdf/ncj175678.pdf

Dolophine (Methadone) drug description - FDA approved labeling for ...

Find Dolophine (Methadone) medication description and FDA approved drug information including side effects, interactions and patient labeling.www.rxlist.com/cgi/generic/methdone.htm

Methadone | CESAR

However, with methadone the gradual and mild onset of action prevents the user ... In the spring of 1971, methadone treatment for opiate dependence began to expand. ...www.cesar.umd.edu/cesar/drugs/methadone.asp

Methadone, Methadone Addiction & Methadone Side Effects By Narconon ...

Heroin & Methadone addiction treatment by Narconon Arrowhead ... methadone info. heroin addiction. heroin treatment admissions ...www.heroinaddiction.com/heroin_methadone.html

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Heroin found in helmet - and cannabis in loft

PanoramaIn two separate drug operations, local Custom Officers have seized 2.1kgs of Cannabis Resin and 1.5g of a preparation containing Diamorphine (Heroin) and 2 tablets of Methadone.http://www.panorama.gi/localnews/headlines.php?action=view_a...

Captive Couriers

Bangor Daily NewsCrushed methadone was wrapped in plastic and placed in the bottom seal of an 8-inch-by-11-inch envelope, which was meticulously peeled open and reglued to hide the drugs.http://www.bangornews.com/detail/90220.html

Southern hub works to prevent spread of HIV

Vietnam NetVietNamNet Bridge – Authorities in Ho Chi Minh City plan to intensify preventive measures to limit the spread of the HIV/AIDS epidemic, according to a conference focusing on a programme aimed at fighting the fatal disease during the 2008-2012 period.http://english.vietnamnet.vn/social/2008/10/806755/

Say no, no, no to the rehab industry

Times OnlineThis year's award for Least Impressive Interviewee on National Radio goes to Paul Hayes, head of the Government's drugs treatment agency. Yesterday, on the Today programme, he inadvertently revealed one of the reasons why drug addiction remains a blight.http://www.timesonline.co.uk/tol/comment/columnists/melanie_...

Police reports - Oct. 3

Ellwood City LedgerWHITE TWP. Drug, weapons charges An Ellwood City man has been charged in two incidents in White Township.http://www.ellwoodcityledger.com/site/news.cfm?newsid=201486...

News about Methadone

Man sentenced to 4 years in toddler drug death

Mansfield News JournalNEWARK, Ohio (AP) — A central Ohio man has been sentenced to four years in prison for his 2-year-old son’s death from drinking liquid methadone. Thirty-four-year-old Daniel Masters of Newark will be eligible for early release after one year ... http://www.mansfieldnewsjournal.com/apps/pbcs.dll/article?AI...

Methadone clinic ordinance is now ready for review

Fosters Daily DemocratSANFORD — The town's draft ordinance for methadone clinics is complete and will be the focus of a town council workshop and a public hearing in the coming weeks. Town Manager Mark Green stated in his weekly report that he and Planning Director Jim ... http://www.fosters.com/apps/pbcs.dll/article?AID=/20080904/G...

Nelly goes to drug rehab

The SunXiguang received daily methadone injections in doses five times larger than those given to a human and has now fully recovered. He is expected to return to the Yunnan Wild Animal Park in the capital of Yunnan province, Kunming, on Saturday.http://www.thesun.co.uk/sol/homepage/news/expats/expats_news...

Addict jailed for giving friend fatal heroin injection

Edinburgh NewsMr Drew also took Valium tablets and a glug of liquid diazepam as well as the heroin substitute Methadone. Then, at about 3pm Pollock yielded to his friend's request for a share of a "wrap" of heroin at Pollock's then home at Riverside Drive ... http://edinburghnews.scotsman.com/latestnews/Addict-jailed-f...

Chinese Elephant Kicks Heroin Addiction

FOX NewsHe was sent to a wildlife facility on the southern island of Hainan, where his treatment involved a year of methadone injections at five times the human dosage.http://www.foxnews.com/story/0,2933,416684,00.html

Search results for Methadone

Methadone Today - Methadone Maintenance Treatment

Methadone Today Works To Correct The Misconceptions About Methadone Maintenance Treatment And To Overcome The Stigma Directed Toward Methadone Patients. ... Methadone Today The ... http://www.methadonetoday.org/

Erowid Methadone Vault

Information on Methadone including research, legislation, media coverage, bibliography and links.http://www.erowid.org/chemicals/methadone/

Methadone - pilison | Google Groups

Methadone. Drug & Opioid Dependence Treatment in the Privacy of a Doctor's Office Compare Rates on CDs, Interest Checking, Savings, Mortgages, Home Equity Loans, Credit Cards and ... http://groups.google.com/group/pilison/web/methadone

Methadone Treatment Centers - Methadone Clinics for Opiate, Heroin ...

Methadone Treatment Directory. A free directory of methadone treatment centers for opiate addiction. Let us help you find a methadone clinic today.http://www.methadonetreatment.net/

Methadone Treatment Centers - Contact Methadone Treatment, Opiate Drug ...

Methadone Treatment Directory. A free directory of methadone treatment centers for opiate addiction. Let us help you find a methadone clinic today.http://www.methadonetreatment.net/assessment/
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Methadone addiction

Methadone addictionIs methadone the largest growing drug problem in the country? CNN's Kitty Pilgrim reports. (February 27)Windows Media - Video

Methadone (Methadose) - video

Methadone (Methadose) - videoA pharmacist explains how Methadose works, why doctors prescribe this powerful pain killer, and common side effects of the drug.Video - Video

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Kicking Heroin

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Kreek.ramInnovations in Methadone and LAAM Treatment Regency Chair: Mary Jeanne Kreek, M.D., Rockefeller University [video] Ronald Brady, M.D., Bridge Plaza Treatment and Rehabilitation Clinicrealmedia: 0 MB w:320px - h:240px

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Answers for Methadone

thibraaniWhere can I get information on Methadone Therapy?thibraanias a member of[JACLF] junkies against crime liberation front.i can tell you plenty about methadone having helped get many people free of this insidiously alleged cure for heroin addiction.this is a c...SeptemberHow long is Methadone rehab and what is the process?SeptemberObviously he is in an inpatient program, cause they do have meth clinics you go to daily. from what you say, 6 yearsof opiate addiction he was probably admitted into a detox first(hospital floor for a...Mike NWhere can I find detailed information on methadone withdrawal?Mike NDO NOT GOTO A METHADONE CLINIC...only about 10% have a legit program that works.Most clinic are just about the money.I will give you 2 options or advice.If she was taking the methadone for pain and it...MelissaHow do you know if someone is smoking crack while on methadone?MelissaThey most likely would be extra, super hyperactive. Non stop movement and talking, no appetite, temper, most likely. Believe me you can tell. This person better be watched cause he or she could pro...ChaliQWhat's the difference between liquid methadone for withdrawel & pill form for pain management?ChaliQHello there. I would like to tell you how sorry I am that you are in so much pain. I also take Methadone for pain and was switched to it after oxycontin no longer helped. I take such high doses that...
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