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Metformin (INN; trade names Glucophage, Riomet, Fortamet, Glumetza, Obimet, Dianben, Diabex, Diaformin, and others) (IPAEng: mɛtˈfɔrmɪn) is an oral anti-diabetic drug from the biguanide class. It is the first-line drug for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function, and evidence suggests it may be the best choice for people with heart failure. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. It is also used in the treatment of polycystic ovary syndrome.

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Wikipedia about metformin

Metformin (INN; trade names Glucophage, Riomet, Fortamet, Glumetza, Obimet, Dianben, Diabex, Diaformin, and others) (IPAEng: mɛtˈfɔrmɪn) is an oral anti-diabetic drug from the biguanide class. It is the first-line drug for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function, and evidence suggests it may be the best choice for people with heart failure. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. It is also used in the treatment of polycystic ovary syndrome.

When prescribed appropriately, metformin causes few adverse effects—the most common is gastrointestinal upset—and, unlike many other anti-diabetic drugs, does not cause hypoglycemia if used alone. It also helps reduce LDL cholesterol and triglyceride levels, and may aid weight loss. , metformin is one of only two oral anti-diabetics in the World Health Organization Model List of Essential Medicines (the other being glibenclamide).(March 2007) , 15th edition, World Health Organization, p. 21. Retrieved on 2007-11-19.

History

The biguanide class of anti-diabetic drugs, which also includes the withdrawn agents phenformin and buformin, originates from the French lilac (Galega officinalis), a plant known for several centuries to reduce the symptoms of diabetes mellitus. PMC: 209536

Metformin was first described in the scientific literature in 1957. It was first marketed in France in 1979, but did not receive approval by the U.S. Food and Drug Administration (FDA) for Type 2 diabetes until 1994. Bristol-Myers Squibb's Glucophage was the first branded formulation of metformin to be marketed in the United States, beginning on March 3, 1995. Generic formulations are now available.

Indications

The main use for metformin is in the treatment of diabetes mellitus type 2, especially when this accompanies obesity and insulin resistance. Metformin is the only anti-diabetic drug that has been proven to reduce the cardiovascular complications of diabetes, as shown in a large study of overweight patients with diabetes. Unlike the other most-commonly prescribed class of oral diabetes drugs, the sulfonylureas, metformin (taken alone) does not induce hypoglycemia. Hypoglycemia during intense exercise has been documented, but is extremely rare. It also does not cause weight gain, and may indeed produce minor weight loss. Metformin also modestly reduces LDL and triglyceride levels.

Search results for Metformin

Metformin

You will need to take metformin with placebo in polycystic ovary syndrome. ... Metformin was used to determine your insulin levels, were not working properly! ...www.hartz.com/Fish/ArticlePreview.asp?Animal=6&Article=2...

Glucophage (Metformin Hcl) drug description - FDA approved labeling for ...

Find Glucophage (Metformin Hcl) medication description and FDA approved drug information including side effects, interactions and patient labeling.www.rxlist.com/cgi/generic/metformi.htm

AmCham Egypt-Tenders Alert Service - View project details (Top Economic ...

Together your, doctor before taking metformin until you are pregnant or if you ... These specific contraindications that metformin must be greater than in the ...www.amcham.org.eg/bic/tas/news/view_projects.asp?project_id=...

AHLA | Career Center

AHLA (American Health Lawyers Association) Web site - The latest health law information. ... Want to stop taking metformin. ... Metformin controls the amount ...www.healthlawyers.org/Template.cfm?Section=Career_Center&...

Rochester Community Schools : :

Care is needed to treat episodes of taking metformin. ... Nonhypoglycemic effects of metformin in obese non-diabetic subjects. ...www.rochester.k12.mi.us/index.aspx?folder=943490771

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News about Metformin

Liraglutide beneficial in type 2 diabetes: Novo Nordisk

PharmaBizData from a phase 3 clinical study (LEAD 4) presented at the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD) demonstrated that adding the investigational new drug liraglutide, a human GLP-1 analogue, to metformin and rosiglitazone in the treatment of type 2 diabetes, leads to improved blood glucose lowering (HbA1c)1, weight loss, blood pressure reduction and ...http://www.pharmabiz.com/article/detnews.asp?articleid=46025

Transition Therapeutics Dose First Patient In Phase 2 Clinical Study Of TT-223 In Type 2 Diabetes

Medical News TodayTransition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ:TTHI, TSX:TTH) announced that the first patient has been dosed in a Phase 2 clinical study of gastrin analogue, TT-223, in patients with type 2 diabetes.http://www.medicalnewstoday.com/articles/121357.php

Transition Therapeutics initiates dosing in Phase II diabetes study

Pharmaceutical Business ReviewCanada-based biopharmaceutical company Transition Therapeutics has announced that the first patient has been dosed in a Phase II clinical study of gastrin analogue, TT-223, in patients with type 2 diabetes.http://www.pharmaceutical-business-review.com/article_news.a...

Five New Studies And Analyses At Major Medical Meeting Further Demonstrate Substantial Efficacy And Robust Clinical ...

Medical News TodayNew data analyses presented at the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD) showed initial combination therapy with the dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin, and metformin provided substantial improvements in blood sugar levels (as measured by HbA1c [2]) over two years of treatment and was generally well tolerated.http://www.medicalnewstoday.com/articles/120909.php

Tests show 2-year benefits of Merck diabetes drug

Reuters via Yahoo! News Merck & Co's diabetes drug Januvia substantially improves blood sugar levels over two years of treatment when combined with the older drug metformin and is generally well tolerated, new data on Tuesday showed.http://news.yahoo.com/s/nm/20080909/hl_nm/merck_januvia_dc_1

News about Metformin

Genaera reports positive data from Phase I study of diabetes and ...

Pharmaceutical Business ReviewStudy MSI-1436C-103 was a double-blind, randomized, placebo-controlled safety and pharmacokinetic (PK) study involving obese or overweight adult male and female diabetic volunteers poorly controlled on metformin. Approximately five subjects in each ... http://www.pharmaceutical-business-review.com/article_news.a...

Lifestyle changes in diabetes fight

Cyprus WeeklyThe drug is a combination form of Metformin and Januvia (sitagliptin) which is has been available on the island for the last year, and is taken as an oral medication twice a day after meals. It is very effective in controlling type 2 diabetes, Horton ... http://www.cyprusweekly.com.cy/default.aspx?FrontPageNewsID=...

Growing Trend: Fatty liver disease in children latest obesity risk

Lubbock Avalanche-JournalThe U.S. government is testing the diabetes drug metformin and vitamin E and is funding about 20 other studies, including one that aims to determine how the disease progresses and who is most likely to develop cirrhosis or liver failure. When her son ... http://lubbockonline.com/stories/100708/liv_341109272.shtml

Uses and How to Use

HealthCentral.comMetformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes (non-insulin-dependent diabetes). Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness ... http://www.healthcentral.com/diabetes/find-drug-1052-150.htm...

Journal Watch

Medscape NewsTo Treat or Not to Treat?... Progression to Dysplasia and Cancer Among BE Patients... Overdiagnosis in Lung Cancer Screening... Inhaled Insulin vs. Metformin for Type 2 Diabeteshttp://www.medscape.com/viewpublication/664_index

Search results for Metformin

Diabetes Monitor - metformin questions and answers

Metformin was approved for use in the U.S. for treatment of type 2 diabetes in December, 1994. It is sold under the brand name Glucophage and is also available generically.http://www.diabetesmonitor.com/metf-qa.htm

metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet ...

Drug information about metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet), a drug used for treating type II diabetes in adults and children.http://www.medicinenet.com/metformin/article.htm

metformin - definition of metformin in the Medical dictionary - by the ...

metformin /met·for·min/ (met-for´min) an antihyperglycemic agent that potentiates the action of insulin, used in the treatment of type 2 diabetes mellitus.http://medical-dictionary.thefreedictionary.com/metformin

METFORMIN • • •

Metformin. Associated Content Check out because it is used to have type 2 diabetes Solid oral hypoglycaemic agent metformin hypersensitivity to the first-line Nature Clinical ... http://nceca.org/pages/info.php?/d/metformin

Mark Isham

Education: METFORMIN! Metformin! Illness or injury basis of this review the sought information from each trial. In the first trimester of ovulation by clomiphene.http://www.dvc.edu/facultyhq/displayhp.asp?homepage_id=1138
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Answers for Metformin

Scorpio Chika

Can metformin cause me to have a miscarriage or affect me getting pregnant?

Scorpio ChikaI would ask my doctor to put me on Clomid. I have heard so much more about that one and the success stories are plentiful. Of course if your periods are very regular, then it is doing what it is suppo...
onefinefeller

What would happen if you overdose on metformin?

onefinefellerIt would be a bad thing for you to increase your metformin without medical supervision. you could easily go into a diabetic coma from hypoglycemia. but then, if you don't get your sugar down, you can ...
koshy57

Is it safe to use metformin in Polycystic ovarian syndrome?

koshy57Yes it is. I have PCOS and have been taking Glucophage XR (Metamorphin is the generic) for years now. I take 2000mg/day. To explain what Glucophage does, I need to help you understand what PCOS...
reese

How long will it take for Metformin to help with my period?

reesemetformin is a drug used to treat diabetes, and lately has been tested for weight loss.... it is not used to treat pcos.
Isabella

Is it safe to take metformin and aspirin at the same time?

IsabellaTalk to your doctor or pharmacist.... bla bla bla... Yes it is save to take ASA for the headaches. I would not take it, however, if you are already on an ASA regimine for your cardiac issues. You mi...

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