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Melanin is a class of compounds found in the plant, animal and protista kingdoms, where it serves predominantly as a pigment. The class of pigments are derivatives of the amino acid tyrosine. The most common form of biological melanin is eumelanin, a brown-black polymer of dihydroxyindole, dihydroxyindole carboxylic acid, and their reduced forms. Another common form of melanin is pheomelanin, a red-brown polymer of benzothiazine units largely responsible for red hair and freckles. The presence of melanin in the archaea and bacteria kingdoms is an issue of ongoing debate amongst researchers in the field. The increased production of melanin in human skin is called melanogenesis. It is stimulated by the DNA damages that are caused by UVB-radiation, and it leads to a delayed development of a tan. This melanogenesis-based tan takes more time to develop, but it is long lasting.
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Wikipedia about melanin
Melanin is a class of compounds found in the plant, animal and protista kingdoms, where it serves predominantly as a pigment. The class of pigments are derivatives of the amino acid tyrosine. The most common form of biological melanin is eumelanin, a brown-black polymer of dihydroxyindole, dihydroxyindole carboxylic acid, and their reduced forms. Another common form of melanin is pheomelanin, a red-brown polymer of benzothiazine units largely responsible for red hair and freckles. The presence of melanin in the archaea and bacteria kingdoms is an issue of ongoing debate amongst researchers in the field. The increased production of melanin in human skin is called melanogenesis. It is stimulated by the DNA damages that are caused by UVB-radiation, and it leads to a delayed development of a tan. This melanogenesis-based tan takes more time to develop, but it is long lasting.
The photochemical properties of melanin make it an excellent photoprotectant. It absorbs harmful UV-radiation and transforms the energy into harmless amounts of heat through a process called "ultrafast internal conversion". This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat and it keeps the generation of free radicals at a minimum (see photoprotection). This prevents the indirect DNA damage which is responsible for the formation of malignant melanoma.
Melanin in humans
In humans, melanin is the primary determinant of human skin color and also found in hair, the pigmented tissue underlying the iris, the medulla and zona reticularis of the adrenal gland, the stria vascularis of the inner ear, and in pigment-bearing neurons within areas of the brain stem, such as the locus ceruleus and the substantia nigra.
Dermal melanin is produced by melanocytes, which are found in the stratum basale of the epidermis. Although human beings generally possess a similar concentration of melanocytes in their skin, the melanocytes in some individuals and ethnic groups more frequently or less frequently express the melanin-producing genes, thereby conferring a greater or lesser concentration of skin melanin. Some individual animals and humans have very little or no melanin in their bodies, a condition known as albinism.
Because melanin is an aggregate of smaller component molecules, there are a number of different types of melanin with differing proportions and bonding patterns of these component molecules. Both pheomelanin and eumelanin are found in human skin and hair, but eumelanin is the most abundant melanin in humans, as well as the form most likely to be deficient in albinism.
Eumelanin polymers have long been thought to comprise numerous cross-linked 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) polymers; recent research into the electrical properties of eumelanin, however, has indicated that it may consist of more basic oligomers adhering to one another by some other mechanism. Thus, the precise nature of eumelanin's molecular structure is once again the object of study. Fact: date=May 2007 Eumelanin is found in hair and skin, and colors hair grey, black, yellow, and brown. In humans, it is more abundant in peoples with dark skin. There are two different types of eumelanin, which are distinguished from each other by their pattern of polymer bonds. The two types are black eumelanin and brown eumelanin, with black melanin being darker than brown. Black eumelanin is in mostly non-Europeans and aged Europeans, while brown eumelanin is in mostly young Europeans. A small amount of black eumelanin in the absence of other pigments causes grey hair. A small amount of brown eumelanin in the absence of other pigments causes yellow (blond) color hair.























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