PBB: geneid=4057 Lactoferrin (LF), also known as lactotransferrin (LTF), is a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum has the highest concentration, followed by human milk, then cow milk.
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Lactoferrin Blog Entries // Blog Post Tag Search // BlogCatalog
Blog Tags. Post Tags. 2 items found. Tag Search Results For 'lactoferrin' (2) ... Lactoferrin for Cats with FIV ... Mobile BlogCatalog Blog TOS BlogCatalog ...www.blogcatalog.com/post-tag/lactoferrin/Lactoferrin, Lactoferrin research, colostrum lactoferrin
Learn about lactoferrin and colostrum lactoferrin at colostrum.lifetips.com. ... we're looking to recruit a Guru to blog, write a 101 tip Colostrum book, and ...colostrum.lifetips.com/cat/60863/lactoferrin/index.htmlThe Biotech Weblog: Lactoferrin And Lysozymes Production From Rice
Lactoferrin and lysozymes are two proteins naturally ... Half of me- The blog behind success. The cinnamon and honey trick. Coffee, good or bad for you? ...www.biotech-weblog.com/50226711/lactoferrin_and_lysozymes_pr...The Motherwear Breastfeeding Blog: Iron supplements for breastfed ...
About a year ago I started getting lots of questions from moms at the ... Lactoferrin has the job of binding with iron in the baby's gut and getting it ...breastfeeding.blog.motherwear.com/2007/03/iron_supplement.ht...The Biotech Weblog: Lactoferrin Aids in Treatment of H. Pylori Infections
... adding a bovine protein called lactoferrin to the existing approaches used to ... Biotech Blog. Biotech Investing. Biotech Licensing. CATO Biotech Directory ...www.biotech-weblog.com/50226711/lactoferrin_aids_in_treatmen...PBB: geneid=4057 Lactoferrin (LF), also known as lactotransferrin (LTF), is a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum has the highest concentration, followed by human milk, then cow milk.
Structure
Lactoferrin belongs to the transferrin family proteins (TF, melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 u (80 kDa). It generally contains two bound Fe+2 ions. It contains 4 identical domains, with two surrounding each iron atom.
Function
Lactoferrin antimicrobial activity is due partly to its high affinity for Fe3+ (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity. The combination of iron and lactoferrin in mucosal secretions modulate the ability and aggregation of pathogenic bacteria, and inhibit both bacteria and viruses by binding to host cells/viral particles. This inhibits the ability of bacteria and viruses to attach to cell membranes. It is also an antifungal agent.
Lactoferrin receptors have been found on brush-border cells, PMN, monocytes, Mφ and activated lymphocytes.
Lactoferrin inhibits dendritic cell-mediated HIV-1 transmission by blocking gp120 to DC-SIGN , which is a critical protein that never changes regardless of strain.
Genetics
In humans, the lactoferrin gene (LTF) is located on chromosome 3; location: 3q21-q23.
External links
- lactoferrinresearch.org
- InVitria - sells Lacromin, a holo-lactoferrin (iron saturated)
- Expasy Database, chemical structure
- LTF on the National Center for Biotechnology Information
- Thompson.net Supported information about lactoferrin.
- FDA Lactoferrin Considered Safe to Fight E. Coli.
- Ventria Bioscience - a source of non-animal breastmilk equivalent lactoferrin
- Agennix.com A biopharmaceutical company focused on developing protein-based drugs for cancer and diabetic ulcers.
- Pharming.com A biopharmaceutical company producing lactoferrin.
