Music

• DJ Jazzy Jeff, an American DJ/turntablist record producer
• Jeff Beck, an electric guitarist
• Jeff Buckley, an American singer-songwriter
• Jeff Graham, a Canadian Radio DJ
• Jeff Hanneman, guitarist for U.S. thrash metal band Slayer
• Jeff Healey, a Canadian blues-rock guitarist
• Jeff Loomis, lead guitarist for heavy metal band Nevermore
• Jeff Lynne, a British singer-songwriter and record producer
• Jeff Mangum, an American singer-songwriter and founder of Neutral Milk Hotel
• Jeff Porcaro, highly regarded session drummer and founding member of Toto
• Jeff Stinco, lead guitarist for pop-punk band Simple Plan
• Jeff Tweedy, an American singer-songwriter and founding member of Wilco

Sports

• Jeff Bagwell, a baseball player
• Jeff Bes, a Canadian ice hockey player
• Jeff Burton, a NASCAR racer
• Jeff Chandler (boxer), a boxing champion
• Jeff Cirillo, a pro baseball player
• Jeff Conine, a pro baseball player
• Jeff Elliott, a British decathlete and pole vaulter
• Jeff Fenech, a boxer
• Jeff Francis, a baseball player
• Jeff Francoeur, a baseball player
• Jeff Garcia, a football player
• Jeff Gordon, a NASCAR racer
• Jeff Guiel, a Canadian baseball player
• Jeff Hardy, a professional wrestler
• Jeff Jarrett, an American professional wrestler
• Jeff Kent, a baseball player
• Jeff Otis, an American football player
• Jeff Speakman, American actor and accomplished martial artist in the art of kempo
• Jeff Stork, an American volleyball player
• Jeff Thomson, an Australian cricketer
• Jeff Van Gundy, a US NBA coach
• Jeff Williams, Australian-born, left-handed pitcher for the Hanshin Tigers baseball team
• Jeff Nielsen Pro hockey player

Literature

• Jeff Noon, a novelist, short story writer and playwright
• Jeff VanderMeer, an American writer

Politics

• Jeff Bingaman, the junior U.S. Senator from New Mexico
• Jeff Flake, a U.S. Representative from Arizona
• Jeff Kennett, former Premier of Victoria, Australia
• Jeff Seemann, a United States Democratic candidate in Ohio for Congress
• Jeff Sessions, the junior U.S. Senator from Alabama

Television and film

• Jeff Anderson, an American actor who appeared as Randal Graves in Kevin Smith's Clerks series
• Jeff Bridges, an American actor
• Jeff Chandler (actor), a 1950s American film actor
• Jeff Cohen, child actor who appeared as Chunk in the 1985 movie The Goonies
• Jeff Conaway, American actor
• Jeff Daniels, an American actor
• Jeff Dunham, an American ventriloquist
• Jeff East, American actor, appeared in Superman as the young Clark Kent
• Jeff Foxworthy, an American comedian and actor
• Jeff Garlin, an American comedic actor
• Jeff Goldblum, an American film actor
• Jeff Maxwell, American actor (Igor from M.A.S.H.)
• Jeff McCarthy, American character actor who has appeared in television, theatre and films
• Jeff Osterhage, American film and television actor
• Jeff Probst, American television personality
• Jeff Thisted, American game show host
• Jeff Yagher, American actor