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Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. Novo Nordisk markets it under the trade name Levemir. It is an insulin analogue in which to the lysine amino acid at position B29 a fatty acid (myristic acid) is bound. It is quickly resorbed after which in the blood it binds to albumin through the fat acid at position B29. It then slowly dissociates from this complex.

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Wikipedia about insulin detemir

Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. Novo Nordisk markets it under the trade name Levemir. It is an insulin analogue in which to the lysine amino acid at position B29 a fatty acid (myristic acid) is bound. It is quickly resorbed after which in the blood it binds to albumin through the fat acid at position B29. It then slowly dissociates from this complex.

In a clinical study (see ref 2) which compared the efficacy and safety of using Levemir for the treatment of patients with type 2 diabetes who had suboptimal glycemic control while receiving maximally tolerated doses of metformin and sulfonylurea (common tablet therapies for type 2 diabetes), it was found that, "At 24 weeks, A1C (glycosylated hemoglobin) had decreased by 1.8 and 1.9% (from 8.6 to 6.8 and from 8.5 to 6.6%) for detemir and NPH, respectively (NS). In both groups, 70% of participants achieved an A1C of 7.0%, but the proportion achieving this without hypoglycemia was higher with insulin detemir than with NPH insulin (26 vs. 16%, P = 0.008). Compared with NPH insulin, the risk for all hypoglycemia with insulin detemir was reduced by 47% (P < 0.001) and nocturnal hypoglycemia by 55% (P < 0.001). Mean weight gain was 1.2 kg with insulin detemir and 2.8 kg with NPH insulin (P < 0.001), and the difference in baseline-adjusted final weight was –1.58 (P < 0.001)."

In short, it was found that insulin detemir reduced Hemoglobin A1C to target levels of 7.0% for 70% of patients, similar to human basal insulin NPH, but without the same risk of hypoglycemia (low blood sugar) and with much lower weight gain.

Similar results have been seen in type 1 diabetes (see ref 3.)

References

1. http://content.nejm.org/cgi/content/full/NEJMoa075392, Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes; Rury R. Holman, M.B., Ch.B., F.R.C.P., Kerensa I. Thorne, M.Sc., Andrew J. Farmer, D.M., F.R.C.G.P., Melanie J. Davies, M.D., F.R.C.P., Joanne F. Keenan, B.A., Sanjoy Paul, Ph.D., Jonathan C. Levy, M.D., F.R.C.P., for the 4-T Study Group

2. http://care.diabetesjournals.org/cgi/content/abstract/29/6/1269?ijkey=2e8d412f27ded6ae0a205b3bfd4d3608ed9b64b5&keytype2=tf_ipsecsha , A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naïve People With Type 2 Diabetes, Kjeld Hermansen, MD1, Melanie Davies, MD2, Taudeusz Derezinski, MD3, Gabrielle Martinez Ravn4, Per Clauson4, Philip Home, DM, DPHIL5 on behalf of the Levemir Treat-to-Target Study Group

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insulin detemir: Information from Answers.com

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Insulin Detemir

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CIGNA - insulin detemir

What should I discuss with my healthcare provider before using insulin detemir? ... What are the possible side effects of insulin detemir? ...www.cigna.com/healthinfo/d05436a1.html

The Pancreas-The Whole Story

Insulin detemir has a fatty acid side chain that allows albumin binding, ... With insulin detemir, administration twice daily is definitely required for ...www.diabetesincontrol.com/issue183/InsulinDetemir.shtml

Insulin - Wikipedia, the free encyclopedia

When insulin glargine or insulin detemir is used, it can be ... 2006 Novo Nordisk Levemir "detemir" insulin analogue approved for clinical use in the US. ...en.wikipedia.org/wiki/Insulin

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News about Insulin Detemir

Sanofi Aventis: New Real Life Studies Illustrate Greater A1C Lowering ...

EIN Newsi) Rosenstock J et al. A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia. 2008 March; 51(3 ... http://www.einnews.com/article.php?nid=4224

Search results for Insulin Detemir

Insulin Detemir - Levemir

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Levemir - Insulin Detemir

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NovoNordisk.com - Levemir Basal Insulin Analogue for Diabetes - Novo ...

Novo Nordisk, a focused healthcare company and world leader in diabetes care, introduces Levemir, a soluble basal insulin analogue for people with type one or type two diabetes.http://www.novonordisk.com/diabetes/levemir_splash.asp

Insulin Detemir (Subcutaneous Route) - MayoClinic.com

Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Description. Insulin is one of many hormones that help the body turn the food we ... http://www.mayoclinic.com/health/drug-information/DR601659

MedlinePlus Drug Information: Insulin Detemir (rDNA Origin ...

Insulin Detemir (rDNA Origin) Injection ... Why is this medication prescribed? Return to top. Insulin detemir is used to treat type 1 diabetes (condition in which the body ... http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a60601...
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Answers for Insulin Detem...

Avinesh

Is Insulin detemir levemir flexpen available in Panama ???

AvineshDont Know but try Contacting "Farmacias Arrocha" It is the biggest pharmacy chain in Panama?

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