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Hepatocellular carcinoma (HCC, also called hepatoma) is a primary malignancy (cancer) of the liver. Most cases of HCC are secondary to either a viral hepatitide infection (hepatitis B or C) or cirrhosis (alcoholism being the most common cause of hepatic cirrhosis). In countries where hepatitis is not endemic, most malignant cancers in the liver are not primary HCC but metastasis (spread) of cancer from elsewhere in the body, e.g. the colon. Treatment options of HCC and prognosis are dependent on many factors but especially on tumor size and staging. Tumor grade is also important. High-grade tumors will have a poor prognosis, while low-grade tumors may go unnoticed for many years, as is the case in many other organs, such as the breast, where a ductal carcinoma in situ (or a lobular carcinoma in situ) may be present without any clinical signs and without correlate on routine imaging tests, although in some occasions it may be detected on more specialized imaging studies like MR mammography (it should be stated, however, that the sensitivity of this technique remains, even with current state-of-the-art technology, below 50%).

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Wikipedia About Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC, also called hepatoma) is a primary malignancy (cancer) of the liver. Most cases of HCC are secondary to either a viral hepatitide infection (hepatitis B or C) or cirrhosis (alcoholism being the most common cause of hepatic cirrhosis). In countries where hepatitis is not endemic, most malignant cancers in the liver are not primary HCC but metastasis (spread) of cancer from elsewhere in the body, e.g. the colon. Treatment options of HCC and prognosis are dependent on many factors but especially on tumor size and staging. Tumor grade is also important. High-grade tumors will have a poor prognosis, while low-grade tumors may go unnoticed for many years, as is the case in many other organs, such as the breast, where a ductal carcinoma in situ (or a lobular carcinoma in situ) may be present without any clinical signs and without correlate on routine imaging tests, although in some occasions it may be detected on more specialized imaging studies like MR mammography (it should be stated, however, that the sensitivity of this technique remains, even with current state-of-the-art technology, below 50%).

The usual outcome is poor, because only 10 - 20% of hepatocellular carcinomas can be removed completely using surgery. If the cancer cannot be completely removed, the disease is usually deadly within 3 to 6 months. This is partially due to late presentation with large tumours, but also the lack of medical expertise and facilities. This is a rare tumor in the United States. A new receptor tyrosine kinase inhibitor, sorafenib has been shown in a Spanish phase III clinical trial to double the lifespan of late stage HCC patients.

Epidemiology

HCC is one of the most common tumors worldwide. The epidemiology of HCC exhibits two main patterns, one in North America and Western Europe and another in non-Western countries, such as those in sub-Saharan Africa, central and Southeast Asia, and the Amazon basin. Males are affected more than females usually and it is more common between the 3rd and 5th decades of life Hepatocellular carcinoma causes 662,000 deaths worldwide per year , about half of them in China.

Non-Western Countries

In some parts of the world, such as sub-Saharan Africa and Southeast Asia, HCC is the most common cancer, generally affecting men more than women, and with an age of onset between late teens and 30s. This variability is in part due to the different patterns of hepatitis B transmission in different populations - infection at or around birth predispose to earlier cancers than if people are infected later. The time between hepatitis B infection and development into HCC can be years, even decades, but from diagnosis of HCC to death the average survival period is only 5.9 months according to one Chinese study during the 1970-80s, or 3 months (median survival time) in Sub-Saharan Africa according to Manson's textbook of tropical diseases. HCC is one of the deadliest cancers in China. Food infected with Aspergillus flavus (especially peanuts and corns stored during prolonged wet seasons) which produces aflatoxin poses another risk factor for HCC.

Search results for Hepatocellular Carcinoma

eMedicine - Hepatocellular Carcinoma : Article by Stuart S Winter

Hepatocellular carcinoma (HCC) is an aggressive hepatic neoplasm that most ... Chlebowski RT, Tong M, Weissman J, et al. Hepatocellular carcinoma. ...www.emedicine.com/ped/topic983.htm

eMedicine - Hepatocellular Carcinoma : Article by Daniel R Jacobson

Hepatocellular carcinoma (HCC) is the most common primary hepatic tumor and one ... Detecting hepatocellular carcinoma: value of unenhanced or arterial phase CT ...www.emedicine.com/radio/topic332.htm

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Get information on liver cancer, its symptoms, causes, diagnosis, staging, prognosis, treatment, and ... What is liver cancer (hepatocellular carcinoma, HCC) ...www.medicinenet.com/liver_cancer/article.htm

Hepatocellular Carcinoma - My Child Has - Children's Hospital Boston

What is hepatocellular (liver) carcinoma? Hepatocellular carcinoma is a rare disease ... Hepatocellular carcinoma may occur in multiple sites within the liver. ...www.childrenshospital.org/az/Site1015/mainpageS1015P0.html

Hepatocellular carcinoma definition - Medical Dictionary definitions of ...

Online Medical Dictionary and glossary with medical definitions ... Primary liver cancer (hepatocellular carcinoma) is the most common cancer in ...www.medterms.com/script/main/art.asp?articlekey=18505

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Medical News TodayPfizer Inc today provided the latest update to its development pipeline, showing significant progress in achieving the company's growth, productivity and performance goals. The pipeline now includes 114 programs, from Phase 1 through Registration. The number in late-stage (Phase 3) development has grown from 16 to 25 over the past six months.http://www.medicalnewstoday.com/articles/123811.php

Pfizer Shows Accelerating Pipeline With Significant Growth In Late-Stage Clinical Development

PharmaceuticalOnlinePfizer Inc. today provided the latest update to its development pipeline, showing significant progress in achieving the company's growth, productivity and performance goals.http://www.pharmaceuticalonline.com/article.mvc/Pfizer-Growt...

DST backed studies show promising results in herbal drug research

PharmaBizA number of initiatives to extract drugs from herbs with potential to treat diseases like cancer, TB, diabetes and Alzheimer's dementia have made some progress under different projects funded by the Department of Science and Technology in the recent past.http://www.pharmabiz.com/article/detnews.asp?articleid=46348

School raises money for student

Community Press & RecorderAmelia Middle School students, faculty and staff raised more than $1,000 for one of the school's eighth-graders, Quinton Roark.http://communitypress.cincinnati.com/apps/pbcs.dll/article?A...

A Promising Anti-Cancer Compound

Medical News TodayNew approaches in cancer therapy that facilitate selective targeting of cancers have been emerging in recent years. Apoptin represents a new anti-cancer tool in such new approaches with great potentials. Two routes can be taken using Apoptin or its encoding cDNA, i.e. as protein therapy or gene therapy.http://www.medicalnewstoday.com/articles/123230.php

News about Hepatocellular Carcinoma

Postseason Insider: Beckett says his OK, others think differently

Rocky Mountain NewsChallis was diagnosed at the age of 16 with Hepatocellular Carcinoma, an adult form of liver cancer. PROUD White Sox owner Jerry Reinsdorf handled the White Sox elimination from the postseason by losing to Tampa Bay in the AL Division Series with classhttp://www.rockymountainnews.com/news/2008/oct/06/postseason...

Journal of Gastroenterology and Hepatology

Medscape NewsYoung HCC Patients vs. Elderly HCC Patients... Chronic Hepatitis B Patients With Persistently Detectable Serum Virus... Hypoxia and Hepatocellular Carcinoma: The Therapeutic Target for HCChttp://www.medscape.com/viewpublication/985_index

How to select anti-hepatitis B virus agents for drug-resistance ...

Genetic Engineering NewsHBV infection may lead to acute liver disease, chronic active hepatitis, liver cirrhosis, and hepatocellular carcinoma. Over 350 million people worldwide are estimated to be infected chronically by HBV and are therefore at risk of liver failure ... http://www.genengnews.com/news/bnitem.aspx?name=42411747

Celsion Provides Update on Its Global Pivotal Phase III Primary Liver ...

Forbes ... Blinded, Dummy-Controlled Study of the Efficacy and Safety of ThermoDox(R) (Thermally Sensitive Liposomal Doxorubicin) in Combination with Radiofrequency Ablation (RFA) Compared to RFA Alone in the Treatment of Non-Resectable Hepatocellular Carcinoma ... http://www.forbes.com/businesswire/feeds/businesswire/2008/0...

A new therapeutic option for human hepatocyte cancer

PhysOrgSo H-1 PV is a suitable agent to circumvent the resistance of p53-negative human hepatocellular carcinoma (HCC) cells to genotoxic agents, and enhances the apoptotic process which is dependent on functional PML. Thus, H-1 PV may be considered as ... http://www.physorg.com/news141378977.html

Search results for Hepatocellular Carcinoma

Hepatocellular Carcinoma

HCC, Hepatocellular, Hepatocellular Carcinoma, Liver Cancer ... This page is not intended as medical advice, it is merely a list of online resources for people interested in liver ... http://liver.andrewtorres.org/

Hepatocellular Carcinoma

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HCV - Hepatocellular Carcinoma

HIVandHepatitis.com: The Internet publication with accurate, timely and cutting-edge information on treatment and vaccines for HIV, AIDS and chronic hepatitis B and hepatitis C ... http://www.hivandhepatitis.com/hep_c/hepc_news_liver_hepatoc...

Hepatocellular carcinoma

Hepatocellular carcinoma accounts for 80% to 90% of all liver cancers. It occurs more often in men than women and occurs mostly in people 50 to 60 years old. The disease is more ... http://www.healthscout.com/ency/1/000280.html

eMedicine - Hepatocellular Carcinoma : Article by Stuart S Winter

Hepatocellular carcinoma (HCC) is an aggressive hepatic neoplasm that most commonly affects adults. Nevertheless, childrhttp://www.emedicine.com/ped/topic983.htm
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Answers for Hepatocellular Carcinoma

jonathan kAspergillus flavus increases the risk of hepatocellular carcinoma?jonathan kyes this is true because that's double exposure. That just like if someone was burned with a match and another was burned with a torch and a match, the match would cause the torch to burn faster and m...blackleuswhere is the best hospital in the U.S. for hepatoma hepatocellular carcinoma (cancer)?blackleusM.D. Anderson Cancer Center in Houston, Texas http://www.mdanderson.org/ It is in amazing place. People come from all over the world to be treated there.Melinda MKnow of a doctor/hospital that specializes in fibrolamellar carcinoma, a type of liver cancer?Melinda MPhiladelphia Childrens Hospital in Center City deals with all kinds of children's cancer. Temple; Drexel University and the Shriner's Hosptial are for chilren and all are in CenterCcity .samiCan Mangosteen reduce the effect of Nexavar?samiI think that it's worth a shot drinking it. I doubt that any drink could have any effect on chemo. I mean, it can't be that strong. Unless they specifically tell you not to drink that juice, go ri...no arFatty infiltrated liver w/ hypoechoic or complex cyst, ultrasoud findings?no ari dont know about that. but i heard that the liver is the only organ that can regenerate. so maybe taking some nutriants that help the liver do its thing would help. i said help not cure, so if...
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