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Haemophilia (also spelled as hemophilia, from the Greek haima "blood" and philia "to love") is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation. In its most common form, Hemophilia A, clotting factor VIII is absent. In Haemophilia B, factor IX is deficient. Hemophilia A occurs in about 1 in 5,000–10,000 male births , while Hemophilia B occurs at about 1 in about 20,000–34,000.

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Wikipedia about hemophilia

Haemophilia (also spelled as hemophilia, from the Greek haima "blood" and philia "to love") is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation. In its most common form, Hemophilia A, clotting factor VIII is absent. In Haemophilia B, factor IX is deficient. Hemophilia A occurs in about 1 in 5,000–10,000 male births , while Hemophilia B occurs at about 1 in about 20,000–34,000.

The effects of this sex-linked, X chromosome disorder are manifested almost entirely in males, although the gene for the disorder is inherited from the mother. Females have two X chromosomes while males have only one, lacking a 'back up' copy for the defective gene. Females are therefore almost exclusively carriers of the disorder, and may have inherited it from either their mother or father. In about 30% of cases of Hemophilia B, however, there is no family history of the disorder and the condition is the result of a spontaneous gene mutation. A mother who is a carrier has a 50% chance of passing the faulty X chromosome to her daughter, while an affected father will always pass on the affected gene to his daughters. A son cannot inherit the defective gene from his father.

These genetic deficiencies may lower blood plasma clotting factor levels of coagulation factors needed for a normal clotting process. When a blood vessel is injured, a temporary scab does form, but the missing coagulation factors prevent fibrin formation which is necessary to maintain the blood clot. Thus a haemophiliac does not bleed more intensely than a normal person, but for a much longer amount of time. In severe haemophiliacs even a minor injury could result in blood loss lasting days, weeks, or not ever healing completely. The critical risk here is with normally small injuries which, due to missing factor VIII, take long times to heal. In areas such as the brain or inside joints this can be fatal or permanently debilitating.

The bleeding with external injury is normal, but incidence of late re-bleeding and internal bleeding is increased, especially into muscles, joints, or bleeding into closed spaces. Major complications include hemarthrosis, hemorrhage, gastrointestinal bleeding, and menorrhagia.

Causes

  • Hemophilia A involves a lack of functional clotting Factor VIII. (This represents 90% of haemophilia cases.)
  • Hemophilia B involves a lack of functional clotting Factor IX.
  • Hemophilia C involves a lack of functional clotting Factor XI.
  • Hypofibrinogenemia involves a lack of functional clotting Factor I. Because it is so rare, about 1 to 2 cases per million births, it has no definite treatment approved by the FDA. It affects males and females equally. The blood of people with Hypofibrinogenemia neither clots nor contains sufficient amounts of Fibrinogen.

Search results for Hemophilia

Haemophilia - Wikipedia

User-edited article about haemophilia, a hereditary genetic illness that impairs the body's ability to control bleeding.en.wikipedia.org/wiki/Haemophilia

Hemophilia - eMedicineHealth

Provides overview, causes, symptoms, treatment, medications, and management of hemophilia, the inherited bleeding disorder in which blood does not clot normally and may become fatal under severe conditions.www.emedicinehealth.com/hemophilia/article_em.htm

How to Deal With Hemophilia

If a person has hemophilia, his blood doesn't clot as it should. What does that mean? ... Hemophilia (say: hee-muh-fih-lee-uh) is a genetic disorder in which a ...kidshealth.org/kid/health_problems/blood/hemophilia.html

BeneFIX

From Wyeth Pharmaceuticals. Site offers background on the disease and treatment for U.S. patients with hemophilia.www.hemophiliavillage.com/

Hemophilia - MayoClinic

Overview of hemophilia, the inherited blood-clotting disorder. Includes symptoms, causes, and treatment of the disease where the blood proteins required for clotting are absent.www.mayoclinic.com/health/hemophilia/DS00218

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News about Hemophilia

HEALTH CARE: Figuring out the best company plan

North County TimesQuestion: My company will offer some new choices for health benefit plans during its open-enrollment period. What are the most important things to consider when picking a plan?http://www.nctimes.com/articles/2008/10/03//business//z18ae5...

11:45 a.m.— Hemophilia symposium set for Friday

Pacific Daily NewsThe Hemophilia Foundation of Guam will be holding a symposium on the bleeding disorder at the Pacific Islands Club in Tumon on Oct. 3.http://www.guampdn.com/apps/pbcs.dll/article?AID=/20080928/N...

FDA Approved Use Of REYATAZ(R) Boosted With Ritonavir, In Combination Therapy, For Previously Untreated HIV-1 Infected ...

Medical News TodayBristol-Myers Squibb Company (NYSE: BMY) announced that the U.S. Food & Drug Administration (FDA) approved the use of REYATAZ® (atazanavir sulfate) 300 mg once-daily boosted with ritonavir 100 mg as part of combination therapy in previously untreated (treatment-naive) HIV-1 infected patients. REYATAZ boosted with ritonavir (REYATAZ/r) taken once daily with food is recognized by the U.S.http://www.medicalnewstoday.com/articles/124005.php

U.S. Food & Drug Administration Approved the use of REYATAZ(R) (atazanavir sulfate) Boosted with Ritonavir, in ...

Centre Daily TimesBristol-Myers Squibb Company (NYSE: BMY) announced today that the U.S. Food & Drug Administration (FDA) approved the use of REYATAZ(R) (atazanavir sulfate) 300 mg once-daily boosted with ritonavir 100 mg as part of combination therapy in previously untreated (treatment-naive) HIV-1 infected patients. REYATAZ boosted with ritonavir (REYATAZ/r) taken once daily with food is recognized by the U.S. .....http://www.centredaily.com/business/technology/story/877745....

Donation provides cancer support

Chicago FlameThe pediatric oncology division of the University of Illinois Medical Center at Chicago recently received a $50,000 donation from the National Greek Orthodox Ladies Philoptochos Society. UIC's division of pediatric hematology/oncology provides services to children and adolescents with cancer, leukemia, sickle cell disease, hemophilia, and other blood disorders.http://www.chicagoflame.com/news/2008/09/29/Pulse/Donation.P...

News about Hemophilia

Injured student’s suit against Tecumseh schools dismissed

Daily TelegramA lawsuit against the Tecumseh school district and an elementary teacher over bullying injuries a first-grade student with hemophilia suffered in 2005 was tossed out of Lenawee County Circuit Court on Monday. No evidence of gross negligence by the ... http://www.lenconnect.com/news/courts/x502300983/Injured-stu...

Doctor publishes book on maladies of royal families

Recorder Community NewspapersRushton’s book focuses on two inherited diseases: hemophilia and porphyria. The first is also known as the bleeder’s disease, a condition in which the sufferer’s blood is deficient in the ability to clot. Rushton believes that the hemophiliac ... http://www.recordernewspapers.com/articles/2008/10/14/hunter...

Blood Supply Slipping as Economy Tumbles

ForbesNYBC provides medical services and programs (Clinical, Transfusion, and Hemophilia Services) through our medical professionals and transfusion medicine physicians. Contact: Leslie Gonzalez Lgonzalez2@nybloodcenter.org (212) 570-3304 Office 646-342 ... http://www.forbes.com/prnewswire/feeds/prnewswire/2008/10/13...

MedPro Rx, Inc. Accepting Drawings For 2009 Penguin Family Calendar

PR InsideRALEIGH, N.C. - Jeff Harper, vice president of hemophilia services for MedPro Rx, Inc. (www.medprorx.com), a provider of specialty pharmacy services to clients with chronic illnesses, has announced that submissions for its 2009 penguin family ... http://www.pr-inside.com/medpro-rx-inc-accepting-drawings-fo...

India to establish plasma fractionation centre

Thaindian.comTransfusion of plasma and administration of plasma fractionation derivatives is indicated for many medical conditions as a life saving measure in conditions such as Hemophilia-A, Hemophilia-B, Von-Willebrnd’s disease, immunodeficiencies and others ... http://www.thaindian.com/newsportal/health/india-to-establis...

Search results for Hemophilia

Hemophilia

Hemophilia is an inherited bleeding disorder. The blood of someone with hemophilia will not clot normally. Bleeding may occur spontaneously or following injury. Hemophilia occurs ... http://www.emedicinehealth.com/hemophilia/article_em.htm

Hemophilia

Dedicated to improving the quality of life for all persons with hemophilia and other inherited bleeding disorders, as well as ensuring the safety of the blood supply for all ... http://www.hemophilia.ca/

Hemophilia

Hemophilia is a rare bleeding disorder that prevents the blood from clotting properly. ... Bumps and scrapes are a part of every child's life. For most kids, a tumble off a bike or ... http://kidshealth.org/parent/medical/heart/hemophilia.html

World Federation of Hemophilia

A global network of healthcare providers, national hemophilia associations, people with hemophilia and their families. Organization history, information about programs ... http://www.wfh.org/

Hemophilia - Genetics Home Reference

Hemophilia is a bleeding disorder that slows the blood clotting process. People with this condition often experience prolonged bleeding or oozing following an injury, surgery, or ... http://ghr.nlm.nih.gov/condition=hemophilia
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Videos found for Hemophilia

Company Looks To Develop Hemophilia...

Company Looks To Develop Hemophilia DrugA simple cut or bruise can be tragic for the more than 300,000 people suffering from hemophilia across the globe. One of Europe's largest pharmaceutical companies is speeding...Flash - Video

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Understanding Global Hemophilia Ca...

 Understanding Global Hemophilia Care- The Global Learning Series... Understanding Global Hemophilia Care- The Global Learning Series The Global Learning Series 26 sec - Jan 23, 2007 Join us for an emotional and visually compelling look at some of the latest vict...flash: 0 MB w:320px - h:240px

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Answers for Hemophilia

Danimal

Is there any way you can have diabetes and hemophilia?

DanimalWow, what an interesting question. I don't know ... you'd think people like that would be untreatable. I'm going to star your question ... because it deserves it and so I won't forget to check back ...
alicefrinker

How common is the disease Hemophilia?

alicefrinkerIt affects about 1 in 10,000 people. I don't know about ethnicity but it is much more common in men than in women. Also it is a condition that you are born with.
amy z

Use a Punnett square to predict the probability that their child will have hemophilia. Can you tell if that ch

amy zHere is a link to a online Punnett square calculator http://www.changbioscience.com/genetics/punnett.html
GiallaBel

Is there such a thing as a less deadly version of hemophilia?

GiallaBelYou can have various functionality of the gene, which is how mild, moderate and severe hemophilia are teased out. But overall, they are pretty bad. Many carriers (women) have a clotting level between...
gnelly23

A woman who is a carrier for royal hemophilia (a sex-linked recessive trait) marries a man who does not have h

gnelly230 girls 1/2 boys

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