Inhibition of glycosaminoglycan synthesis and protein glycosylation ...
Human IAPP (hIAPP) is amyloidogenic and in vitro studies have shown that early aggregates or oligomers of hIAPP are cytotoxic, leading to β-cell death via apoptosis (12, 22).
Decoding protein structures helps illuminate cause of diabetes
Any photographer can vouch for the difficulty of capturing a clear picture ... in type II diabetes has been linked to toxic clumps of the protein hIAPP (human ...
Plasma insulin and glucos... - Yale Image Finder
To investigate the roles of hIAPP and islet amyloid in DM2, we generated transgenic mice expressing hIAPP in their islet beta cells. In this study, we found that after a long-term ...
EMU Chemistry -- Faculty/Staff
It is known that insulin, which is co-secreted with hIAPP from the beta-cell, acts as an inhibitor of hIAPP’s oligomerization and eventual aggregation.
β-Cell glucokinase deficiency and hyperglycemia are ...
The resulting new (hIAPP×GKKO) line of mice had higher basal plasma glucose ... no islet amyloid was observed in GKKO mice lacking the hIAPP transgene (0 of 13) ...
Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis ...
Why do hIAPP oligomers (and amyloid) form? Given the potent mechanisms in place to prevent intracellular oligomerization of amyloidogenic proteins such as hIAPP, why does this fail in ...
Calcium elevation in mouse pancreatic beta cells e...[Diabetologia ...
Decreasing the activity of TRPV4 prevented hIAPP-induced [Ca(2+)](i) changes, reduced hIAPP-triggered ER stress and improved cell viability. PMID: 18751967 [PubMed - indexed for ...
Extended life span is associated with insulin resistance in a ...
hIAPP transgenic mice (C57BL/6 x DBA/2) were bred from a previously described ... These mice produce hIAPP in their islets and secrete the peptide with insulin in ...
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Aim 2: To study the mechanism of hIAPP oligomer/protofibril formation on the surface of membrane liposomes and to determine the size of the aggregates leading to pore formation and ...
Recent Insights in Islet Amyloid Polypeptide-Induced Membrane ...
The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide (hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the ...
