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Gout (also called metabolic arthritis) is a disease created by a buildup of uric acid. In this condition, monosodium urate or uric acid crystals are deposited on the articular cartilage of joints, tendons and surrounding tissues due to elevated concentrations of uric acid in the bloodstream. This provokes an inflammatory reaction of these tissues.

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Gout Blog

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The Gout Blog by Gout Aware

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Wikipedia About Gout

Gout (also called metabolic arthritis) is a disease created by a buildup of uric acid. In this condition, monosodium urate or uric acid crystals are deposited on the articular cartilage of joints, tendons and surrounding tissues due to elevated concentrations of uric acid in the bloodstream. This provokes an inflammatory reaction of these tissues.

Signs and symptoms

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Gout usually attacks the big toe (approximately 75 percent of first attacks); however, it also can affect other joints such as the ankle, heel, instep, knee, wrist, elbow, fingers, and spine. In some cases, the condition may appear in the joints of small toes that have become immobile due to impact injury earlier in life, causing poor blood circulation that leads to gout.

Patients with long-standing hyperuricemia (see below) can have uric acid crystal deposits called tophi (singular: tophus) in other tissues such as the helix of the ear. Elevated levels of uric acid in the urine can lead to uric acid crystals precipitating in the kidneys or bladder, forming uric acid kidney stones.

Diagnosis

Clinically, gout can be hard to distinguish from several other conditions, including chondrocalcinosis. Chondrocalcinosis is a very similar disease, caused by deposition of calcium pyrophosphate rather than uric acid.

Hyperuricemia is a common feature of gout, so its presence supports a diagnosis of gout. However, gout can occur without hyperuricemia.

Hyperuricemia is defined as a plasma urate (uric acid) level greater than 420 μmol/L (7.0 mg/dL) in males, or 380 μmol/L in females. However, a high uric acid level does not necessarily mean a person will develop gout. Urate is within the normal range in up to two-thirds of cases.

If gout is suspected, the serum urate test should be repeated once the attack has subsided. Other blood tests commonly performed are full blood count, electrolytes, renal function, thyroid function tests and erythrocyte sedimentation rate (ESR). This helps to exclude other causes of arthritis, most notably septic arthritis, and to investigate any underlying cause for the hyperuricaemia.

A definitive diagnosis of gout is from light microscopy of fluid aspirated from the joints (this test may be difficult to perform) to demonstrate intracellular monosodium urate crystals in synovial fluid polymorphonuclear leukocytes. The urate crystal is identified by strong negative birefringence under polarised microscopy and its needle-like morphology. A trained observer does better in distinguishing them from other crystals.

Pathogenesis

Gout occurs when mono-sodium urate crystals form on the articular cartilage of joints, on tendons, and in the surrounding tissues. Purine metabolism gives rise to uric acid, which is normally excreted in the urine. Uric acid is likely to form into crystals when there is a hyperuricemia, although it is 10 times more common without clinical gout than with it.

Search results for Gout

Gout - Wikipedia

User-edited article about Gout, also called metabolic arthritis, the disease caused by a buildup of uric acid.en.wikipedia.org/wiki/Gout

Gout (Gouty Arthritis) - WebMD

Read about gouty arthritis, its causes such as high-purine diet and uric acid, its symptoms of pain, swelling, and inflammation, as well as its treatments including medication and reduced alcohol intake.www.webmd.com/a-to-z-guides/gout-topic-overview

Questions and Answers About Gout - NIAMS

General information about the disease, including tips on what people with gout can do to stay healthy. From the National Insitute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).www.niams.nih.gov/Health_Info/Gout/

Gout - Arthritis.org

Information on gout, a form of arthritis that causes sudden, severe attacks of pain and tenderness in some joints.ww2.arthritis.org/conditions/DiseaseCenter/gout.asp

Gout - familydoctor.org

Information about gout from the American Academy of Family Physicians. Includes who can get a gout attack, what should one do if he or she has a gout attack, and its possible treatment.www.familydoctor.org/handouts/372.html

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News about Gout

Demjanjuk appeals German court decision

AP via Yahoo! NewsSuspected Nazi death camp guard John Demjanjuk launched an appeal in a Berlin court Thursday to try to halt his deportation to Germany, his attorney told The Associated Press.http://news.yahoo.com/s/ap/20090507/ap_on_re_eu/eu_germany_d...

'Unprecedented Times' Force Ardea to Lay Off Nearly Half of Employees

San Diego Business JournalJust a week after announcing a licensing pact with Bayer HealthCare worth up to $407...http://www.sdbj.com/article.asp?aID=136880

Supreme Court rejects final deportation appeal

The Columbus DispatchCLEVELAND (AP) -- Alleged Nazi death-camp guard John Demjanjuk lost his bid yesterday to get the U.S. Supreme Court to stop his deportation to Germany. There, an arrest warrant accuses him of 29,000 counts of accessory to murder during World War II. The legal case spans more than three decades.http://www.dispatch.com/live/content/local_news/stories/2009...

(AFX UK Focus) 2009-05-08 14:48 UPDATE 1-Ardea to cut nearly half of its workforce, posts loss

Interactive InvestorSAYS CUTTING 47 PCT WORKFORCE * Q1 loss/shr $0.79 vs estimates $0.76 May 8 (Reuters) - Biotechnology company Ardea Biosciences Inc posted a wider-than-expected quarterly loss, hurt by higher research and development costs, and said it would cut about 47 percent of its workforce to focus its resources on its clinical-stage programs.http://www.iii.co.uk/news/?type=afxnews&articleid=7311439&su...

High Court: No Appeal From Accused Nazi

CBS NewsAlleged Nazi death camp guard John Demjanjuk lost his bid Thursday to get the U.S. Supreme Court to stop his deportation to Germany, where an arrest warrant accuses him of 29,000 counts of accessory to murder during World War II.http://www.cbsnews.com/stories/2009/05/07/national/main49995...

News about Gout

Matching Wine With the Bird

WHO-TVAs the French say, "Chacun a' son goût," which means something like "Who am I to tell my relatives what to drink on Thanksgiving?" * * 1996 Marietta Cellars, Sonoma County, $15. It is ripe, rounded, sweet and juicy with lots of direct, berryish fruit ... http://www.whotv.com/la-thanksgiving-wine,0,7287943.story

Cop who championed rights for disabled people retires

San Francisco GateThe unsanitary conditions also led to tenant Todd McCullough getting his feet amputated after gout in his leg became infected and he developed gangrene, according to court filings. But McCullough wants to stay in the apartment he's lived in for the ... http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2009/05/02/...

Supreme Court denies Demjanjuk's deportation plea

Guardian UnlimitedDemjanjuk has said he suffers severe spinal, hip and leg pain and has a bone marrow disorder, kidney disease, anemia, kidney stones, arthritis, gout and spinal deterioration. The case dates back more than 30 years. In 1977, the Justice Department ... http://www.guardian.co.uk/world/feedarticle/8497242

Demjanjuk to appeal to Supreme Court

Boston GlobeDemjanjuk has said he suffers severe spinal, hip, and leg pain and has a bone marrow disorder, kidney disease, anemia, kidney stones, arthritis, gout, and spinal deterioration.http://www.boston.com/news/nation/articles/2009/05/06/demjan...

High urate levels may ward off Parkinson's disease

ReutersWhile too much urate can cause problems like gout, it does have powerful antioxidant properties -- and this could protect neurons in the brain against damage. "We found that higher (blood) urate concentration was associated with lower occurrence of ... http://www.reuters.com/article/healthNews/idUSTRE54458120090...

Search results for Gout

Gout (Gouty Arthritis) Overview: Gout Causes, Symptoms, Diagnosis, and ...

Read about gouty arthritis causes (high-purine diet, uric acid), symptoms (pain, swelling, inflammation), diagnosis, and treatment (medication, reducing alcohol intake).http://www.webmd.com/a-to-z-guides/Gout-Topic-Overview

What Is Gout - www.gout.com

Learn more about the causes and symptoms of gout as well as the long-term effects this disease can have on the body. Also look for gout myths vs gout facts and information on who ... http://www.gout.com/what_is_gout/what_is_gout.aspx

Gout - Overview - Incidence and Prevalence - podiatrychannel

Comprehensive info for consumers about gout including patient information about gout and gout incidence and prevalence. Physician-developed health information.http://www.podiatrychannel.com/gout/index.shtml

Gout on Kosmix

Signs And Symptoms. Symptoms of gout almost always occur suddenly, especially at night. Gout causes the joints to become red, swollen, and stiff.http://health.kosmix.com/topic/Gout

Gout -- familydoctor.org

Information about gout from the American Academy of Family Physicians.http://familydoctor.org/online/famdocen/home/articles/372.ht...

Wikipedia results for Gout

Gout - Wikipedia, the free encyclopedia

Gout is a disease hallmarked by elevated levels of uric acid in the bloodstream. In this condition, crystals of monosodium urate (MSU) or uric acid are deposited on the articular ... http://en.wikipedia.org/wiki/Gout

Henri Gout - Wikipedia, the free encyclopedia

Henri Gout (b. 9 November 1876 d. 7 December 1953) was a French politician. Born in Badens , he studied medicine before becoming involved in politics as a member of the Radical ... http://en.wikipedia.org/wiki/Henri_Gout

Uric acid - Wikipedia, the free encyclopedia

... High uric acid Gout. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. [8] Elevated serum uric acid (hyperuricemia) can result from high intake of ... http://en.wikipedia.org/wiki/Uric_acid

Colchicine - Wikipedia, the free encyclopedia

Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the ... http://en.wikipedia.org/wiki/Colchicine

Allopurinol - Wikipedia, the free encyclopedia

Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. [1]http://en.wikipedia.org/wiki/Allopurinol
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Answers for Gout

Perak Manwhat is the best way to control gout problem?Perak ManWhat Should You Eat when you are diagnosed with gout? Dietary restrictions suggest what people should not eat, but what should people eat? What foods will help control gout attacks? The American Me...nachtrieb2What will happen if Gout is left untreated? Or if the person with gout does not stop their alcohol intake?nachtrieb2The medication should help stop the gout attack. The alcohol causes the body to produce more uric acid. This makes it harder for the gout medication to work. The alcohol consumption in most people...drcdesHow can I get rid of soreness from gout?drcdesHi, 38yr old male battling gout for 13yrs, doc says hereditary mainly. Two BLT's in a day and I'm on the sickening med's the next day...colchricine. You name the med I've been on it. Once the crystal'...wickedsoxf4nWhat are some good treatment options for gout?wickedsoxf4nI wrote this answer in a previous question : I use all of the following remedies. But curently I use the Apple Cider Vinegar and regular celery intake as per below. Cherry juice can work but it...❀Hapagirl❀ 海樂How long does it take for gout in the foot to heal?❀Hapagirl❀ 海樂I had gout attacks that were gone in 3 days or some that took 2 weeks, but my last one is still here like 2 months later. My swelling has gone down, but I still have trouble getting my shoes on and my...
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