Alvocidib - Wikipedia, the free encyclopedia
Alvocidib (INN; also known as Flavopiridol or HMR-1275) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
P-TEFb - Wikipedia, the free encyclopedia
Genes and Development 11:2622-2632. ^ Chao, S-H., Price, D.H. (2001) "Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo."
Flavopiridol Binds to Duplex DNA -- Bible et al. 60 (9): 2419 ...
Flavopiridol Binds to Duplex DNA 1 Keith C. Bible 2, Roy H. Bible, Jr., Timothy J. Kottke, Phyllis A. Svingen, Kun Xu, Yuan-Ping Pang, Elisabeth Hajdu and Scott H. Kaufmann
Flavopiridol enhances tumor response to radiotherapy - ASCO
Flavopiridol enhances tumor response to radiotherapy - ASCO - The American Society of Clinical Oncology (ASCO) is the world's leading professional organization representing ...
flavopiridol [PharmGKB]
Generic Names: Alvocidib; CPB; Flavo; Flavopiridol hydrochloride; HMR-1275; flavopiridol: IUPAC Name: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl ...
Flavopiridol for Previously Treated CLL - National Cancer Institute
In this clinical trial, researchers are testing the ability of a drug called flavopiridol to cause the remission of chronic lymphocytic leukemia that arises in a ...
Flavopiridol for Previously Treated CLL - National Cancer Institute
In this clinical trial, researchers are testing the ability of a drug called flavopiridol to cause the remission of chronic lymphocytic leukemia that arises in a class of ...
Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib ...
The most effective P-TEFb inhibitor flavopiridol was evaluated against HIV-1 in ... Flavopiridol and seliciclib showed modest cytotoxicity when tested in clinical ...
GIST Support International - Alvocidib (flavopiridol)
GIST Support International is a support group of patients and families affected by gastrointestinal stromal tumor. GIST Support International is dedicated to education and support ...
Transcription inhibition by flavopiridol: mechanism of chronic ...
Flavopiridol is active against chronic lymphocytic leukemia (CLL) cells in vitro ... This study demonstrated that flavopiridol inhibited the phosphorylation of the ...
Chronic Lymphocytic Leukemia: A Niche for Flavopiridol? -- Brown 11 (11 ...
Flavopiridol, a synthetic flavone related to a natural product of the bark of a ... Flavopiridol selectively inhibits multiple cdks by blocking ATP binding and by ...
Search of: "Flavopiridol" - List Results - ClinicalTrials.gov
Flavopiridol in Treating Patients With Previously Untreated or Relapsed ... Flavopiridol Plus Radiation Therapy Followed By Gemcitabine in Treating Patients ...
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed ...
Flavopiridol, a cytotoxic small-molecule antineoplastic agent being evaluated in ... Although flavopiridol was initially identified as a cytostatic inhibitor of ...
Novel Approaches to the Treatment of Cancer
As a single agent, flavopiridol (HMR1275), a CDK inhibitor, was given in doses ... In addition to CDK inhibition, flavopiridol has demonstrated an ability to ...
ALEXIS Biochemicals: Flavopiridol
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) ... Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate ...
Blood -- Bortezomib and flavopiridol interact synergistically to induce ...
Flavopiridol/bortezomib effectively induced apoptosis in these cells in ... The capacity of flavopiridol to promote bortezomib-mediated Bcr/Abl down ...
Flavopiridol, a Cyclin-dependent Kinase Inhibitor, Enhances ...
Flavopiridol, a cyclin-dependent kinase (cdk) inhibitor, can cause cell cycle ... In addition, flavopiridol treatment (300 nM, 1 day) resulted in decreased levels ...
A Phase II Study of Flavopiridol in Patients With Previously Untreated ...
Purpose. Flavopiridol is a potent cyclin-dependent kinase (CDK) inhibitor that has preclinical activity in many tumours. This synthetic flavonoid was tested in a phase II ...
