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Venlafaxine (Effexor, Efexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of major depression and anxiety disorders, among other uses. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide, it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the number of retail prescriptions in the US (17.1 million) in 2006.

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Wikipedia about effexor

Venlafaxine (Effexor, Efexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of major depression and anxiety disorders, among other uses. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide, it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the number of retail prescriptions in the US (17.1 million) in 2006.

Approved

Venlafaxine is used primarily for the treatment of major depression, generalized anxiety disorder, social anxiety disorder, and panic disorder in adults.

Depression

Venlafaxine was shown to be effective for depression in multiple double blind studies. Venlafaxine is similar in efficacy to the tricyclic antidepressants amitriptyline (Elavil) and imipramine and it was better tolerated than amitriptyline. Venlafaxine appears to have efficacy similar or somewhat better than sertraline (Zoloft) and fluoxetine (Prozac) depending on the criteria and rating scales used. In particular, higher doses of venlafaxine are more effective, and more patients achieved remission or were "very much improved". At the same time the efficacy was similar if the number of patients who achieved "response" or were "improved" was considered. A meta-analysis comparing venlafaxine and combined groups of SSRI or tricyclic antidepressants indicated superiority of venlafaxine. Based on the same set of criteria, venlafaxine was similar in efficacy to an atypical antidepressant bupropion (Wellbutrin); however, the remission rate was significantly lower for venlafaxine. Venlafaxine was also marginally inferior in efficacy to a newer SSRI escitalopram (Lexapro) and had twice higher frequency of the side effects, in particular, nausea, ejaculation disorder, somnolence and sweating. In a double-blind study, patients who did not respond to an SSRI were switched to venlafaxine or citalopram. Similar improvement was observed in both groups.

A popular magazine Consumer Reports, which in 2004 had rated venlafaxine as the most effective among six commonly prescribed antidepressants, no longer recommends it. Fluoxetine, citalopram and bupropion have been chosen as Consumer Reports Best Buy drugs in the updated version of their guide, based upon effectiveness, safety, side effects, and cost.

Off-label / investigational uses

Many doctors are starting to prescribe venlafaxine "off label" for the treatment of diabetic neuropathy (in a similar manner to duloxetine) and migraine prophylaxis (in some people, however, venlafaxine can exacerbate or cause migraines). Studies have shown venlafaxine's effectiveness for these conditions. It has also been found to reduce the severity of 'hot-flashes' in menopausal women.

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News about Effexor

Lawsuit over antidepressant headed to trial

The Daily RecordA federal lawsuit over plans for a generic version of the antidepressant Effexor XR cannot be resolved without a trial, a federal judge in Baltimore ruled.http://www.mddailyrecord.com/article.cfm?id=8716&type=UTTM

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The Palm Beach PostOn Sunday nights, when I am trying to figure what I can wear to work that does not need ironing, I fill my little blue pill box for the week. Three pills in each little box. Twenty-one pills a week.http://www.palmbeachpost.com/news/content/accent/epaper/2008...

Age-Old Treatment Eases Hot Flashes

ThirdAgeSep. 23 -- Acupuncture may be just as effective as drug therapy for treating hot flashes in breast cancer patients with premature menopause , according to a study released today from the Henry Ford Health Systems.http://www.thirdage.com/menopause/age-old-treatment-eases-ho...

Embracing menopause

The Naperville SunThe baby boomer generation coming of age brought the issue of menopause - "the change of life" - out in the open. http://www.suburbanchicagonews.com/napervillesun/lifestyles/...

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Newark Star-LedgerI was really up out of the dumps today and totally needed that let down! You people need to go on Effexor, or just stop having miserable lives. Seriously, it's been the same broken record from cranky conservatives in this state since before Florio. If ... http://www.nj.com/news/index.ssf/2008/10/bruce_springsteen_l...

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CNBCSo it's good news for the company that, according to Thomson Scientific and IMS Health, drugs that represent $77 billion in sales -- Prevacid, Lipitor, Effexor and others -- will lose their patents over the next five years. Medco [ MHS   Loading ... http://www.cnbc.com/id/22301895

Types Of Anxiety Disorders

WNEP-TV 16These include selective serotonin reuptake inhibitors (such as fluoxetine [Prozac], sertraline [Zoloft], fluvoxamine [Luvox], paroxetine [Paxil], citalopram [Celexa] and venlafaxine [Effexor]) tricyclic anti-depressants (such as imipramine and ... http://www.wnep.com/global/story.asp?s=1230400

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Answers for Effexor

Loria W

How long do the side effects of effexor last?

Loria Whey i am currently on effexor and yes its really a b itch. its a tradeoff at do you want sex...or no anxietty? i tried many meds and effexor actually has the least amount of sexual interfering side ef...
trick_melody

is it possible to take effexor and not have any sexual side effects?

trick_melody
wrigley

How long will it take for Effexor to get out of my system?

wrigleyIt takes a long time to get out of your system. Did you just stop? How many mg. were you on? You may want to supplement with amino acids - 5 HTP and L Tyrosine untill the "brain shivers" go away...
liliy4evanaday

How long does a withdraw from Effexor last?

liliy4evanadayComing off any med requires a closely monitored plan from your psych or GP. My psych brought me off of 450mg/day of Effexor in 1 week (I don't see him anymore). This resulted in me being in a whee...
bianca_ca777

How well does effexor work for social anxiety?

bianca_ca777I was on Effexor and I could not sleep. My Doctor switch me to "Klonopin" (1mg) the same that the actress "Jodi Foster" takes, but it also requires a sleep aid. I've been given "Seroquel" (!00mg) and...

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