Methamphetamine ( listen) also known as metamfetamine (INN), dextromethamphetamine, methylamphetamine, N-methylamphetamine, and desoxyephedrine) is a psychostimulant and sympathomimetic drug. Methamphetamine enters the brain and triggers a cascading release of dopamine and norepinephrine. It is highly active in the mesolimbic reward pathways of the brain, inducing intense euphoria, with a high potential for addiction. To a lesser extent, methamphetamine releases serotonin and acts as a dopaminergic and adrenergic reuptake inhibitor, with higher concentrations serving as a monoamine oxidase inhibitor. Users may become hypersexual or obsessed with a task, thought or activity. Withdrawal is characterized by excessive sleeping, eating, and depression, often accompanied by anxiety and drug-craving. Methamphetamine users may take sedatives, such as benzodiazepines, as a means of easing their comedown, anxiety or difficulty sleeping.

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