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Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

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Wikipedia About Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

  • Glucocorticoids such as cortisol control carbohydrate, fat and protein metabolism and are anti-inflammatory by preventing phospholipid release, decreasing eosinophil action and a number of other mechanisms.
  • Mineralocorticoids such as aldosterone control electrolyte and water levels, mainly by promoting sodium retention in the kidney.

Some common natural hormones are corticosterone (C21H30O4), cortisone (C21H28O5, 17-hydroxy-11-dehydrocorticosterone) and aldosterone.

Biosynthesis

Corticosteroid-biosynthetic-pathway-rat.png

Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is either mediated by the aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they share 11β-hydroxylation and 18-hydroxylation functions). But aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zona fasciculata and reticularis.

Uses

Synthetic drugs with corticosteroid-like effect are used in a variety of conditions, ranging from brain tumors to skin diseases. Dexamethasone and its derivatives are almost pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect. Fludrocortisone (Florinef) is a synthetic mineralocorticoid. Hydrocortisone (cortisol) is available for replacement therapy, e.g. in adrenal insufficiency and congenital adrenal hyperplasia.

Synthetic glucocorticoids are used in the treatment of joint pain or inflammation (arthritis), temporal arteritis, dermatitis, allergic reactions, asthma, hepatitis, systemic lupus erythematosus, inflammatory bowel disease (ulcerative colitis and Crohn's disease), sarcoidosis and for glucocorticoid replacement in Addison's disease or other forms of adrenal insufficiency. Topical formulations for treatment of skin, eye diseases (uveitis) or inflammatory bowel disease are available. Corticosteroids are also used supportively to prevent nausea, often in combination with 5-HT3 antagonists (e.g. ondansetron).

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Corticosteroid injections for rotator cuff disorders

Drug details for Corticosteroid injections for rotator cuff disorders. ... The effectiveness of corticosteroid injections can vary. ...www.webmd.com/a-to-z-guides/corticosteroid-injections-for-ro...

HON Allergy Glossary Corticosteroid

HON Allergy Glossary, Corticosteroid: Hormone (class of steroid ) obtained from the cortex of the adrenal gland or drug (manufactured synthetically such as prednisone)www.hon.ch/Library/Theme/Allergy/Glossary/corticosteroid.htm...

Takayasu's Arteritis And Cortiscosteroids

Various corticosteroid syrups are available for children. ... Pulse corticosteroid treatment is a serious procedure that involves risks. ...www.takayasus.org/corticosteroid.htm

CORTICOSTEROIDS - ORAL side effects, medical uses, and drug interactions.

Consumer information about the medication CORTICOSTEROIDS - ORAL , includes side ... USES: This medication is a corticosteroid. It reduces swelling. ...www.medicinenet.com/corticosteroids-oral/article.htm

Definition of corticosteroid - NCI Dictionary of Cancer Terms

Virtual and Standard Colonoscopy Both Accurate. NCI Responds to Hurricanes. The Nation's Investment in Cancer ... corticosteroid (KOR-tih-koh-STAYR-oyd) ...www.nci.nih.gov/Templates/db_alpha.aspx?CdrID=45658

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Caution when assuming pain is carpal tunnel

Stratford City GazetteQ: Recently, I've had pain and tingling in my fingers, making it harder for me to do routine tasks. Do I have carpal tunnel syndrome? What can I do to ease the pain?http://www.stratfordgazette.com/lifestyle/article/56856

Self-Adjusted Dosing May Be The Best Treatment For Hay Fever

Medical News TodayHay fever, the often seasonal allergy that affects between 10 and 20 percent of the American population, is best controlled through a course of patient-adjusted dosing, according to new research published in the September 2008 edition of Otolaryngology - Head and Neck Surgery.http://www.medicalnewstoday.com/articles/123799.php

A.P. Pharma Announces Positive Phase 3 Results With APF530 In The Prevention Of Chemotherapy Induced Nausea And Vomiting

Medical News TodayA.P. Pharma, Inc. (NASDAQ:APPA), a specialty pharmaceutical company, announced today positive results from its pivotal Phase 3 study comparing te efficacy of APF530 (the Company's proprietary, sustained release formulation of granisetron) with Aloxi® for the prevention of chemotherapy induced nausea and vomiting (CINV).http://www.medicalnewstoday.com/articles/123722.php

High Growth Reported for the World Pulmonary Drug Delivery Technologies Market

Marketwire via Yahoo! Finance Reportlinker.com announces that a new market research report related to the Pharmaceutical industry industry is available in its catalogue.http://biz.yahoo.com/iw/081001/0439470.html

Hay fever may be best treated with self-adjusted dosing

EurekAlert!( American Academy of Otolaryngology -- Head and Neck Surgery ) Hay fever, the often seasonal allergy that affects between 10 and 20 percent of the American population, is best controlled through a course of patient-adjusted dosing, according to new research published in the September 2008 edition of Otolaryngology -- Head and Neck Surgery.http://www.eurekalert.org/pub_releases/2008-10/aaoo-hfm09300...

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Therapeutic Options for Pediatric Atopic Dermatitis Reviewed CME

Medscape NewsConcerns about potential long-term risks for corticosteroid use, particularly in young children, have been to some extent alleviated by recent evidence. Regimens of corticosteroid therapy may include starting treatment with a more potent preparation ... http://www.medscape.com/viewarticle/581761

Isotechnika announces first sale of voclosporin

Pharmaceutical Business ReviewThree separate clinical (Luminate) trials are currently investigating Luveniq as a corticosteroid-sparing agent for the treatment of patients with non-infectious uveitis, an autoimmune disease characterized by chronic inflammation of the eye and one ... http://www.pharmaceutical-business-review.com/article_news.a...

Hay fever may be best treated with self-adjusted dosing

Science CentricDuring the study by Thai researchers, hay fever, known clinically as allergic rhinitis, was observed in 69 patients, who were then treated over the course of 28 days with the intranasal corticosteroid triamcinolone acetonide. Patients with mild ... http://www.sciencecentric.com/news/article.php?q=08100988

Recovering from the effects of Bell's palsy

Bridgeton NewsRecent studies have shown a benefit in patients treated with a corticosteroid such as prednisone. Often, prednisone and an antiviral medicine, such as acyclovir, are prescribed. Most people will fully recover, even without receiving any treatment. ... http://www.nj.com/healthfit/ledger/index.ssf?/base/living-0/...

Landmark UPLIFT Study Shows That Spiriva Improves Lung Function And ...

Medical News TodayNearly two-thirds of patients were on a long-acting beta-agonist and/or an inhaled corticosteroid at baseline, increasing to three-quarters by the end of the study. This may explain the lack of impact on FEV 1 decline compared to the control group in ... http://www.medicalnewstoday.com/articles/124338.php

Search results for Corticosteroid

corticosteroid definition of corticosteroid in the Free Online ...

corticosteroid drug (kôr'təkōstâr`oid), any one of several synthetic or naturally occurring substances with the general chemical structure of steroids steroids, class of lipids ... http://encyclopedia2.thefreedictionary.com/corticosteroid

corticosteroid drug – FREE corticosteroid drug Information ...

corticosteroid drug – Facts about corticosteroid drug, Pictures, Video and corticosteroid drug Information at Encyclopedia.com: a free, credible collection of encyclopedias.http://www.encyclopedia.com/doc/1E1-corticos-drg.html

corticosteroid - Wiktionary

Definition from Wiktionary, a free dictionaryhttp://en.wiktionary.org/wiki/corticosteroid

Corticosteroid Side Effects by MedicineNet.com

Read about corticosteroids and their possible side effects. ... Corticosteroid Side Effects. Interview with Dr. Dennis Lee, and Dr. William C.http://www.medicinenet.com/script/main/art.asp?articlekey=13...

corticosteroid: meaning and definitions — Infoplease.com

corticosteroid: Definition and Pronunciationhttp://dictionary.infoplease.com/corticosteroid
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Answers for Corticosteroi...

WorddeuceWhat should I expect when I go in to get a corticosteroid injection in my neck for herniated discs?WorddeuceI have had this done to my lower back. It can be done 2 ways, either with a light sedative, or not. You lay on an x-ray machine so it can be precise. The shot I get hurts a lot. I felt the pain sho...prima_donna1986When do the effects of prednisolone(corticosteroid)start wearing off?prima_donna1986Use of prednisolone for a continuous 4 months would have caused some side effects in you. There would have been retention of fluids, changes in appetite, acne, moonface, skin striae etc. You may have...maddee4cI take medication with a corticosteroid. Does the weight gain ever stop?maddee4cI asked this very question of my kids doctor today. He said eventually it will level off and when or if you are taken off the meds the weight will go away over a few weeks. Has something to do with t...wisdomtoothEczema: Should I avoid exposing skin treated with corticosteroid cream to direct sunlight?wisdomtoothActually,it does matter when you use corticosteroids because the use causes de-pigmentation and thinning of your skin.If you use them and expose youtrself to sunlight,your skin will lack protection f...swchadabHow do you pronounce steroid in the corticosteroid sense (not anabolic)?swchadab
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