Cleopatra VII Philopator (in Greek, Κλεοπάτρα Φιλοπάτωρ; January 69 BC – 30 BC) was a Hellenistic ruler of Egypt, originally sharing power with her father Ptolemy XII and later with her brothers/husbands Ptolemy XIII and Ptolemy XIV; eventually gaining sole rule of Egypt. As Pharaoh, she consummated a liaison with Gaius Julius Caesar that solidified her grip on the throne. After Caesar's assassination, she aligned with Mark Antony, with whom she produced a set of twins and a son. Cleopatra had four children in all, firstly, a born son by Caesar (Ptolemy Caesar nicknamed Caesarion), and three by Mark Antony (the twins, Cleopatra Selene II and Alexander Helios, and a son Ptolemy Philadelphus). Her successive unions with her brothers produced no children. Her reign marks the end of the Hellenistic Era and the beginning of the Roman Era in the eastern Mediterranean. She was the last Pharaoh of Ancient Egypt. Her son by Julius Caesar, Caesarion, co-ruled in name with his mother only a very few years before Octavian, later on renamed Caesar Augustus, had him executed, most probably by strangulation, which in Antiquity was the execution method reserved for infants and pre-pubescents, thus adding humiliation to his execution.

Though she bore the ancient Egyptian title Pharaoh, her main language was Greek; for several centuries preceding her rule, Egyptian kings had been of Macedonian Greek (i.e. Hellenistic) origin rather than Egyptian origin. The establishment of a Greek aristocracy in Egypt had come with Alexander the Great nearly 300 years before. Cleopatra is reputed to have been the first member of her family in their 300-year reign in Egypt to have learned the Egyptian language. Cleopatra adopted common Egyptian beliefs and deities. Her patron goddess was Isis, and thus during her reign it was believed that she was the re-incarnation and embodiment of the goddess of wisdom.

After Antony and Cleopatra were defeated at Actium by their rival and Caesar's legal heir, Gaius Julius Caesar Octavian (who later became the first Roman Emperor, Augustus), Cleopatra committed suicide, the traditional date being 12 August 30 BC, allegedly by means of an asp bite. To this day she remains popular in Western culture. Her legacy survives in numerous works of art and the many dramatizations of her story in literature (e.g. Shakespeare's Antony and Cleopatra and George Bernard Shaw's Caesar and Cleopatra), film, and television (e.g. Elizabeth Taylor's depiction in Cleopatra, and the BBC–HBO co-production Rome).

In most depictions, Cleopatra is put forward as a great beauty and her successive conquests of the world's most powerful men is taken to be proof of her aesthetic and sexual appeal. In his Pensées, philosopher Blaise Pascal contends that Cleopatra's classically beautiful profile changed world history: "Cleopatra's nose, had it been shorter, the whole face of the world would have been changed."