A callus (or callosity) is an especially toughened area of skin which has become relatively thick and hard in response to repeated friction, pressure, or other irritation. Rubbing that is too frequent or forceful will cause blisters rather than allow calluses to form. Since repeated contact is required, calluses are most often found on feet because of frequent walking. Guitarists often also develop calluses on their fingertips due to the frequent friction on the strings. Bowlers will often develop calluses on the thumb as well as their middle and ring fingers due to the friction caused in releasing the ball. Bicycle riders can also get calluses especially if they are not wearing gloves. Calluses are generally not harmful, but may sometimes lead to other problems, such as skin ulceration or infection.

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