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Antipsychotics are a group of psychoactive drugs commonly but not exclusively used to treat psychosis, which is typified by schizophrenia. Over time a wide range of antipsychotics have been developed. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s. Most of the drugs in the second generation, known as atypical antipsychotics, have more recently been developed. Both classes of medication tend to block receptors in the brain's dopamine pathways, but antipsychotic drugs encompass a wide range of receptor specificity. A number of side effects have been observed in relation to specific medications, including weight gain, agranulocytosis, tardive dyskinesia, tardive akathisia and tardive psychoses. The development of new antipsychotics, and the relative efficacy of different ones, is an important ongoing field of research. Antipsychotic medication is not generally regarded as a good treatment so much as the best available, and the most appropriate drug for an individual patient requires careful consideration.

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Wikipedia About Antipsychotic

Antipsychotics are a group of psychoactive drugs commonly but not exclusively used to treat psychosis, which is typified by schizophrenia. Over time a wide range of antipsychotics have been developed. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s. Most of the drugs in the second generation, known as atypical antipsychotics, have more recently been developed. Both classes of medication tend to block receptors in the brain's dopamine pathways, but antipsychotic drugs encompass a wide range of receptor specificity. A number of side effects have been observed in relation to specific medications, including weight gain, agranulocytosis, tardive dyskinesia, tardive akathisia and tardive psychoses. The development of new antipsychotics, and the relative efficacy of different ones, is an important ongoing field of research. Antipsychotic medication is not generally regarded as a good treatment so much as the best available, and the most appropriate drug for an individual patient requires careful consideration.

Terminology

Antipsychotics are also referred to as neuroleptic drugs. The word neuroleptic is derived from Greek: "νεύρον" (originally meaning sinew but today referring to the nerves) and "λαμβάνω" (meaning take hold of). Thus, the word means taking hold of one's nerves. This term reflects the drugs' ability to make movement more difficult and sluggish, which clinicians previously believed indicated that a dose was high enough.Fact: date=August 2007 The lower doses used currently have resulted in reduced incidence of motor side effects and sedation, and the term is less commonly used than in the past..

Antipsychotics are broadly divided into two groups, the typical or first-generation antipsychotics and the atypical or second-generation antipsychotics. There are also dopamine partial agonists, which are often categorized as atypicals.

Typical antipsychotics are also sometimes referred to as major tranquilizers, because some of them can tranquilize and sedate. This term is increasingly disused, as the terminology implies a connection with benzodiazepines ("minor" tranquilizers) when none exists.

Usage

Common conditions with which antipsychotics might be used include schizophrenia, mania, and delusional disorder. They might be used to counter psychosis associated with a wide range of other diagnoses, such as psychotic depression. In addition, these drugs are used to treat non-psychotic disorders. For example, some antipsychotics (haloperidol, pimozide) are used off-label to treat Tourette syndrome, whereas Aripiprazole is prescribed in some cases of Asperger's syndrome.

History

The original antipsychotic drugs were happened upon largely by chance and were tested empirically for their effectiveness. The first antipsychotic was chlorpromazine, which was developed as a surgical anesthetic. It was first used on psychiatric patients because of its powerful calming effect; at the time it was regarded as a "chemical lobotomy". Lobotomy was used to treat many behavioral disorders, including psychosis, although its "effectiveness" was (from a modern viewpoint) due to its tendency to markedly reduce behavior of all types. However, chlorpromazine quickly proved to reduce the effects of psychosis in a more effective and specific manner than the extreme lobotomy-like sedation it was known for.

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The Antipsychotics

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Atypical Antipsychotic Medications

The atypical antipsychotic medications are the first line treatment for Schizophrenia. ... Antipsychotic Meds What is Depression?Video Game Violence What is ...mentalhealth.about.com/cs/schizophrenia/a/atypical.htm

Antipsychotic drugs, atypical

The "conventional" antipsychotic drugs are classified by their chemical ... All of the atypical antipsychotic agents are chemically classified as dibenzepines. ...www.healthatoz.com/healthatoz/Atoz/ency/antipsychotic_drugs_...

Antipsychotic Medications - Mental Health Disorders on MedicineNet.com

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Atypical Antipsychotic Drugs

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End the spectre of science for sale

ZDNetIf the law and regulations are not being violated, if only ethics are involved, then science for sale becomes standard practice. http://healthcare.zdnet.com/?p=1403

Forest Laboratories, Inc. And Gedeon Richter Plc Announce Positive Phase II Results With The Investigational ...

Medical News TodayForest Laboratories, Inc. (NYSE: FRX) and Gedeon Richter Plc announced preliminary top-line results from a phase II clinical trial of cariprazine (RGH-188), an investigational antipsychotic, in patients with acute mania associated with bipolar I disorder.http://www.medicalnewstoday.com/articles/123610.php

ImClone Buyout Talks Continue With Large Drugmaker (Update4)

BloombergOct. 2 (Bloomberg) -- ImClone Systems Inc ., the biotechnology company controlled by billionaire Carl Icahn , said last night a large drugmaker is continuing to negotiate a formal proposal to buy the biotechnology company.http://www.bloomberg.com/apps/news?pid=20601202&sid=aojXXndr...

Top Scoops

Scoop.co.nz(Wash. DC) Accused "unregistered Iraqi agent", Susan Lindauer, is now challenging the September 15th decision of federal district court Judge Loretta Preska, which continues to find Lindauer to be "incompetent to stand trial."http://www.scoop.co.nz/stories/HL0810/S00055.htm

ImClone Buyout Talks Continue With Second Drugmaker (Update3)

BloombergOct. 2 (Bloomberg) -- ImClone Systems Inc ., the cancer drugmaker controlled by billionaire Carl Icahn , said last night a second large drugmaker is continuing to negotiate a formal proposal to buy the biotechnology company.http://www.bloomberg.com/apps/news?pid=20601202&sid=arLRXCx7...

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Fitch places Lilly ratings on negative watch list

ForbesThe credit rating service said this leverage would become even more sensitive to the company as it attempts to reduce operating costs ahead of patent expirations on drugs like the antipsychotic Zyprexa. Fitch placed several Lilly ratings on negative ... http://www.forbes.com/feeds/ap/2008/10/06/ap5515500.html

Eli Lilly settles Zyprexa inquiries in 32 states

Washington PostResize NEW YORK -- Eli Lilly & Co. said Tuesday it will pay $62 million to resolve investigations into the marketing and promotion of its antipsychotic drug Zyprexa in 32 states and Washington, D.C. The payments will be divided between the states ... http://www.washingtonpost.com/wp-dyn/content/article/2008/10...

Florida to get $3.6M as Eli Lilly settles over Zyprexa

St. Petersburg TimesFlorida will receive $3.6-million as part of a $62-million settlement with Eli Lilly & Co. to resolve a probe into how it marketed its antipsychotic drug Zyprexa. The settlement will be split between 32 states. Florida Attorney General Bill McCollum ... http://www.tampabay.com/news/health/medicine/article842453.e...

Lilly to acquire ImClone for $6b

Boston GlobeYesterday, he said Lilly's price "vindicated" his opposition to a 2006 buyout offer worth $36 per share. Lilly will lose patent protection for its two top-selling drugs, the antipsychotic Zyprexa and the antidepressant Cymbalta, in 2011 and 2013 ... http://www.boston.com/business/healthcare/articles/2008/10/0...

UPDATE: Lilly Settles 32-State Zyprexa Marketing Probe For $62 Million

CNN MoneyNEW YORK -(Dow Jones)- Eli Lilly & Co. (LLY) will pay $62 million to settle 32 state investigations into how it marketed its blockbuster antipsychotic treatment Zyprexa. The agreement is a step in the Indianapolis drug maker's efforts to resolve ... http://money.cnn.com/news/newsfeeds/articles/djf500/20081007...

Search results for Antipsychotic

Antipsychotic Drugs Information on Healthline

Definition Antipsychotic drugs are a class of medicines used to treat psychosis and other mental and emotional conditions. Purpose Psychosis is defined ashttp://www.healthline.com/galecontent/antipsychotic-drugs

Antipsychotic Medications - Mental Health Disorders on MedicineNet.com

Learn about mental health info includes addiction, anxiety, depression, food and diet, sex, stress, and work related issues.http://www.medicinenet.com/script/main/art.asp?articlekey=26...

Antipsychotic Medications

Background information on antipsychotic medications, potency comparisons, drug name cross reference, and links to other resources.http://members.aol.com/leonardjk/drugs.htm

Atypical Antipsychotic Initiative

Prior authorization information regarding atypical antipsychotics. The Official Website of the Office of Health and Human Services (EOHHS)http://www.mass.gov/?pageID=eohhs2terminal&L=6&L0=Home&L1=Pr...

Atypical Antipsychotic Drugs Information

Atypical Antipsychotic Information ... Atypical Antipsychotic Drugs Information. Aripiprazole (marketed as Abilify)http://www.fda.gov/cder/drug/infopage/antipsychotics/default...
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Anti-Psychotic Monkey Dope: The Cur...

Anti-Psychotic Monkey Dope: The Cure For A.D.H.D.?Why do I have a beard? I was involved in my first feature film as an actor for the last 2 weeks. I'll talk more about that in the near future. I shaved off my beard last night....Flash - Video

Drugging our Children w/ Psychiatry...

Drugging our Children w/ Psychiatry’s Antipsychotic DrugsBe My Friend - http://www.myspace.com/psychtruth See the PBS Frontline Documentary online http://www.pbs.org/wgbh/pages/frontline/medicatedchild/ Drugging our Children w/...Windows Media - Video

Keep Pounds Off While On Anti-Psych...

Keep Pounds Off While On Anti-Psychotic MedsResearchers have found a way to keep children's weight under control, while taking such medication. Harold Greene reports.Windows Media - Video

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Connect With Kids: Anti-Psychotic D...

Connect With Kids: Anti-Psychotic Drug Use IncreasingA soaring number of children are being prescribed a controversial class of drugs called "anti-psychotics." Research shows that the number of kids taking these drugs has increased...Video - Video

Answers for Antipsychotic

Chris HAre there any vitamins that can help counteract some of the side effects of antipsychotic drugs?Chris HI'm bipolar & have real depressed spells too. I have to take several different antipsychotic drugs. I take a multivitamin, B-Complex (very good for mental health). Also fish oil (Omega 3 oils)., Vit...neesh3Is treating schizophrenia with therapy more beneficial than treating it with an antipsychotic medication?neesh3Cognitive behavioral therpay does not acknowledge the transpersonal/spiritual nature of schizophrenia and therefore it is questionable just how much it can help. It can help some because I use it mys...vivaldi558Which antipsychotic is best for a schizophrenic patient who likes to drink?vivaldi558None. Most psychiatric drugs have the side effect of making you drowsy so definitely these drugs and alcohol should not be mixed. She should either stop drinking and start with the medication or con...Robert EWhere in the Philippines can i find Risperdal, an antipsychotic drug?Robert EMercury Drugstore and other big pharmacy stores around. Don't forget your prescription because Risperdal is antipsychotic and therefore a controlled drug. Prices may be high because its a branded med ...AngeleHow many prescriptions have been written this year for the antipsychotic drug Haloperidol?Angelebecause it is a generic drug, there is no way of tracking that information accurately. But from the political ads on TV- I'd say not enough prescriptions filled yet.
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