{{drugbox | IUPAC_name = (S)-1-1pyrrolidine-2-carbonitrile |synonyms = (2S)-1-{2-2acetyl}pyrrolidine-2-carbonitrile | image = Vildagliptin Structural Formulae.png | width = 140 | CAS_number = 274901-16-5 | ATC_prefix = A10 | ATC_suffix = BH02 | ATC_supplemental =
ATC: BD08 (with metformin) | PubChem = 6918537 | DrugBank = | C = 17 |H = 25 |N = 3 |O = 2 | molecular_weight = 303.399 g/mol | bioavailability = 85% | protein_bound = 9.3% | metabolism = Mainly hydrolysis to inactive metabolite; CYP450 not appreciably involved | elimination_half-life = 2 to 3 hours | excretion = Renal | pregnancy_category = Not recommended | legal_UK = POM | legal_status = | routes_of_administration = Oral }} Vildagliptin (previously identified as LAF237, trade name Galvus) is a new oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIPMentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem. 1993 Jun 15;214(3):829-35. PMID 8100523. by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas.

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